Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design - Wikidata - thesis-toulmin - TriplyDB

Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design

Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design

http://www.wikidata.org/entity/Q27665912

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PKA RIα Homodimer Structure Reveals an Intermolecular Interface with Implications for Cooperative cAMP Binding and Carney Complex Disease A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMP Disrupting the allosteric interaction between the Plasmodium falciparum cAMP-dependent kinase and its regulatory subunit Interaction of Mycobacterium tuberculosis RshA and SigH is mediated by salt bridges The auto-inhibitory role of the EPAC hinge helix as mapped by NMR Predicting Allosteric Effects from Orthosteric Binding in Hsp90-Ligand Interactions: Implications for Fragment-Based Drug Design Electrostatic Switch Function in the Mechanism of Protein Kinase A Iα Activation: Results of the Molecular Dynamics Simulation.Signaling through dynamic linkers as revealed by PKA Substrate-induced conformational changes in Plasmodium falciparum guanosine monophosphate synthetase.Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIα activation in response to cAMP binding Cyclic nucleotide binding and structural changes in the isolated GAF domain of Anabaena adenylyl cyclase, CyaB2.Tandem Domains with Tuned Interactions Are a Powerful Biological Design Principle.Allostery through the computational microscope: cAMP activation of a canonical signalling domain Noncognate DNA damage prevents the formation of the active conformation of the Y-family DNA polymerases DinB and DNA polymerase κ Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling.Ligand-mediated changes in conformational dynamics of NpmA: implications for ribosomal interactions.β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase.HDX-MS takes centre stage at unravelling kinase dynamics.Probing allosteric mechanisms using native mass spectrometry.DIRECT-ID: An automated method to identify and quantify conformational variations--application to β2 -adrenergic GPCR.A tool set to map allosteric networks through the NMR chemical shift covariance analysis.Crystal structure of cGMP-dependent protein kinase Iβ cyclic nucleotide-binding-B domain : Rp-cGMPS complex reveals an apo-like, inactive conformation.Allosteric regulation of PKCθ: understanding multistep phosphorylation and priming by ligands in AGC kinases.A novel allosteric site in casein kinase 2α discovered using combining bioinformatics and biochemistry methods.PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination.Role of arginine 209 in the conformational transition of the protein kinase A regulatory subunit RIα A-domain.Neutron Crystallography Detects Differences in Protein Dynamics: Structure of the PKG II Cyclic Nucleotide Binding Domain in Complex with an Activator.Reversing allosteric communication: From detecting allosteric sites to inducing and tuning targeted allosteric response.

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Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design

http://www.wikidata.org/entity/Q27665912

description

2011 nî lūn-bûn

@nan

2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Cyclic AMP Analog Blocks Kinas ...... in Allosteric Inhibitor Design

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Cyclic AMP Analog Blocks Kinas ...... in Allosteric Inhibitor Design

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Cyclic AMP Analog Blocks Kinas ...... in Allosteric Inhibitor Design

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type

label

Cyclic AMP Analog Blocks Kinas ...... in Allosteric Inhibitor Design

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Cyclic AMP Analog Blocks Kinas ...... in Allosteric Inhibitor Design

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Cyclic AMP Analog Blocks Kinas ...... in Allosteric Inhibitor Design

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Cyclic AMP Analog Blocks Kinas ...... in Allosteric Inhibitor Design

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Cyclic AMP Analog Blocks Kinas ...... in Allosteric Inhibitor Design

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Cyclic AMP Analog Blocks Kinas ...... in Allosteric Inhibitor Design

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MCP.M110.004390

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Molecular & Cellular Proteomics

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Cyclic AMP Analog Blocks Kinas ...... in Allosteric Inhibitor Design

@en

P2093

Choel W Kim

http://www.w3.org/2001/XMLSchema#string

Ganesh S Anand

http://www.w3.org/2001/XMLSchema#string

Gao Yunfeng

http://www.w3.org/2001/XMLSchema#string

Jian Wu

http://www.w3.org/2001/XMLSchema#string

Lin Qingsong

http://www.w3.org/2001/XMLSchema#string

Mark Ritchie

http://www.w3.org/2001/XMLSchema#string

Pearl Akamine

http://www.w3.org/2001/XMLSchema#string

Suguna Badireddy

http://www.w3.org/2001/XMLSchema#string

Susan S Taylor

http://www.w3.org/2001/XMLSchema#string

P2860

High-speed and high-resolution UPLC separation at zero degrees Celsius

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Structure and regulation of the cAMP-binding domains of Epac2

PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation

Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains

Automated protein model building combined with iterative structure refinement

AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR

The CCP4 suite: programs for protein crystallography

Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA

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M110.004390

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scholarly article

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1075485

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10.1074/MCP.M110.004390

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3

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10

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Kunchithapadam Swaminathan

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2011-03-01T00:00:00Z

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47809161

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21081668

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allosteric inhibitor

P932

3047156

http://www.w3.org/2001/XMLSchema#string