ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.
about
Structural Insights into Ring Formation of Cohesin and Related Smc ComplexesATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to AdaptorThe Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human CancerDouble strand binding-single strand incision mechanism for human flap endonuclease: implications for the superfamilyMechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeThe Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesEmerging critical roles of Fe-S clusters in DNA replication and repair.ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complexMre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repairStructural and functional insights into DNA-end processing by the archaeal HerA helicase-NurA nuclease complexStructural insights into the regulation of cohesion establishment by Wpl1DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease ActivitiesStructure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signalingATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signalingEnd-resection at DNA double-strand breaks in the three domains of lifeDNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex.Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairTel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand BreaksRare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening studyDeveloping advanced X-ray scattering methods combined with crystallography and computationA Structure-free Method for Quantifying Conformational Flexibility in proteins.Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source.End resection at double-strand breaks: mechanism and regulation.XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase.Systems biology: confronting the complexity of cancer.Autoinhibition of bacteriophage T4 Mre11 by its C-terminal domain.Integrative structural modeling with small angle X-ray scattering profiles.Sequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11ARecognition and repair of chemically heterogeneous structures at DNA endsCharacterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law.Evidence for distinct functions of MRE11 in Arabidopsis meiosis.Mre11-Rad50 complex crystals suggest molecular calisthenics.The Rad50 coiled-coil domain is indispensable for Mre11 complex functionsDeprotonated imidodiphosphate in AMPPNP-containing protein structuresDNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons.ATP hydrolysis by RAD50 protein switches MRE11 enzyme from endonuclease to exonuclease.Interdependence of the rad50 hook and globular domain functionsFunctional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil DomainDisruption of the bacteriophage T4 Mre11 dimer interface reveals a two-state mechanism for exonuclease activity
P2860
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P2860
ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
ABC ATPase signature helices i ...... Mre11 interface for DNA repair
@nl
ABC ATPase signature helices i ...... re11 interface for DNA repair.
@ast
ABC ATPase signature helices i ...... re11 interface for DNA repair.
@en
type
label
ABC ATPase signature helices i ...... Mre11 interface for DNA repair
@nl
ABC ATPase signature helices i ...... re11 interface for DNA repair.
@ast
ABC ATPase signature helices i ...... re11 interface for DNA repair.
@en
prefLabel
ABC ATPase signature helices i ...... Mre11 interface for DNA repair
@nl
ABC ATPase signature helices i ...... re11 interface for DNA repair.
@ast
ABC ATPase signature helices i ...... re11 interface for DNA repair.
@en
P2093
P2860
P50
P3181
P356
P1476
ABC ATPase signature helices i ...... Mre11 interface for DNA repair
@en
P2093
Andrew S Arvai
Gareth J Williams
Grant Guenther
Jessica S Williams
Paul Russell
R Scott Williams
Soumita SilDas
P2860
P2888
P304
P3181
P356
10.1038/NSMB.2038
P577
2011-03-27T00:00:00Z
P5875
P6179
1039725960