Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection
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Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode ClassificationIn silico discovery of aminoacyl-tRNA synthetase inhibitorsCrystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug designStructures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase InhibitorsInhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetasesThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsNovel hybrid virtual screening protocol based on molecular docking and structure-based pharmacophore for discovery of methionyl-tRNA synthetase inhibitors as antibacterial agentsLigand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organismsComparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases.Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening.Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites.From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.Inhibition of isoleucyl-tRNA synthetase as a potential treatment for human African Trypanosomiasis.Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target.A multiple aminoacyl-tRNA synthetase complex that enhances tRNA-aminoacylation in African trypanosomes.Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei.Protein Flexibility in Drug Discovery: From Theory to Computation.Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.Pharmacological Potential and Synthetic Approaches of Imidazo[4,5-b]pyridine and Imidazo[4,5-c]pyridine Derivatives.Rate Constants and Mechanisms of Protein-Ligand Binding.Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.Structural characterization of free-state and product-state Mycobacterium tuberculosis methionyl-tRNA synthetase reveals an induced-fit ligand-recognition mechanism.
P2860
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P2860
Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection
description
2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Distinct States of Methionyl-t ...... ng by Conformational Selection
@ast
Distinct States of Methionyl-t ...... ng by Conformational Selection
@en
Distinct States of Methionyl-t ...... ng by Conformational Selection
@nl
type
label
Distinct States of Methionyl-t ...... ng by Conformational Selection
@ast
Distinct States of Methionyl-t ...... ng by Conformational Selection
@en
Distinct States of Methionyl-t ...... ng by Conformational Selection
@nl
prefLabel
Distinct States of Methionyl-t ...... ng by Conformational Selection
@ast
Distinct States of Methionyl-t ...... ng by Conformational Selection
@en
Distinct States of Methionyl-t ...... ng by Conformational Selection
@nl
P2093
P2860
P1433
P1476
Distinct states of methionyl-t ...... ng by conformational selection
@en
P2093
Christophe L M J Verlinde
Erkang Fan
J Robert Gillespie
Jessica E Kim
Mingyan Yu
Ranae M Ranade
Sayaka Shibata
Wim G J Hol
P2860
P304
P356
10.1016/J.STR.2012.07.011
P577
2012-08-16T00:00:00Z