Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation
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PLAID: a Syndrome of Complex Patterns of Disease and Unique PhenotypesFine specificity and molecular competition in SLAM family receptor signallingRegions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligandsCompetition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion.The autoinhibitory C-terminal SH2 domain of phospholipase C-γ2 stabilizes B cell receptor signalosome assembly.Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.Angioimmunoblastic T cell lymphoma: novel molecular insights by mutation profiling.Recurrent PTPRB and PLCG1 mutations in angiosarcoma.Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions.Effect of acute acid-base disturbances on the phosphorylation of phospholipase C-γ1 and Erk1/2 in the renal proximal tubule.Inhibiting the Recruitment of PLCγ1 to Kaposi's Sarcoma Herpesvirus K15 Protein Reduces the Invasiveness and Angiogenesis of Infected Endothelial CellsScaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation.Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1.Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase CγFGF-1 Triggers Pannexin-1 Hemichannel Opening in Spinal Astrocytes of Rodents and Promotes Inflammatory Responses in Acute Spinal Cord Slices.Cooperative Control of Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling by an Unusual Array of Redundant Repressive Elements.Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes.Weak protein-ligand interactions studied by small-angle X-ray scattering.The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein.Comparative analysis of interactions of RASSF1-10.PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment.Endothelial cell malignancies: new insights from the laboratory and clinic.Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMRFunctional characterization of phospholipase C-γ mutant protein causing both somatic ibrutinib resistance and a germline monogenic autoinflammatory disorder
P2860
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P2860
Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation
description
2012 nî lūn-bûn
@nan
2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structural and Functional Inte ...... sms and Signaling Deregulation
@ast
Structural and Functional Inte ...... sms and Signaling Deregulation
@en
Structural and Functional Inte ...... sms and Signaling Deregulation
@nl
type
label
Structural and Functional Inte ...... sms and Signaling Deregulation
@ast
Structural and Functional Inte ...... sms and Signaling Deregulation
@en
Structural and Functional Inte ...... sms and Signaling Deregulation
@nl
prefLabel
Structural and Functional Inte ...... sms and Signaling Deregulation
@ast
Structural and Functional Inte ...... sms and Signaling Deregulation
@en
Structural and Functional Inte ...... sms and Signaling Deregulation
@nl
P2093
P2860
P50
P1433
P1476
Structural and Functional Inte ...... sms and Signaling Deregulation
@en
P2093
Ambrose Cole
Corine Mas-Droux
Diego Esposito
Ekatarina Lamber
Matilda Katan
Rhona W Baxendale
P2860
P304
P356
10.1016/J.STR.2012.09.005
P577
2012-12-05T00:00:00Z