Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
about
LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressorComplement C1q activates canonical Wnt signaling and promotes aging-related phenotypesStructural basis of Wnt recognition by FrizzledStructural basis of agrin-LRP4-MuSK signalingStructural Studies of Wnts and Identification of an LRP6 Binding SiteStructural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondinStructural Insights into the Inhibition of Wnt Signaling by Cancer Antigen 5T4/Wnt-Activated Inhibitory Factor 1Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafishLRP5 and LRP6 in development and diseaseMutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibitionIntrinsic disorder in spondins and some of their interacting partners.The LRP6 rs2302685 polymorphism is associated with increased risk of myocardial infarction.Disulfide bond requirements for active Wnt ligands.Three decades of Wnts: a personal perspective on how a scientific field developed.The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells.The Wnt/β-catenin pathway in human fibrotic-like diseases and its eligibility as a therapeutic target.High Bone Mass-Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors In VivoBoth LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.Rational design of DKK3 structure-based small peptides as antagonists of Wnt signaling pathway and in silico evaluation of their efficiencyFrizzled and LRP5/6 receptors for Wnt/β-catenin signalingThe sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3β-E2F1 Axis Linking Reversely with Survival in Gliomas.The way Wnt works: components and mechanism.Low-density lipoprotein receptor-related protein 6 is a novel coreceptor of protease-activated receptor-2 in the dynamics of cancer-associated β-catenin stabilization.Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.Rationale for targeting the Wnt signalling modulator Dickkopf-1 for oncology.Celebrating 30 years of Wnt signaling.Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf.Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase.Structural architecture and functional evolution of WntsLRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α2δ-1 subunit.Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons.New horizons for lipoprotein receptors: communication by β-propellers.The structural basis of DKK-mediated inhibition of Wnt/LRP signalingWnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerizationResonance assignment and secondary structure determination of full length human Dickkopf 4 (hDkk4), a secreted, disulphide-rich Wnt inhibitor protein.Sequence and structural difference favors a distinct preference of Wnt3a binding with co-receptor LRP6.How multi-scale structural biology elucidated context-dependent variability in ectodomain conformation along with the ligand capture and release cycle for LDLR family members.
P2860
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P2860
Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
description
2011 nî lūn-bûn
@nan
2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
@ast
Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
@en
Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
@nl
type
label
Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
@ast
Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
@en
Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
@nl
prefLabel
Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
@ast
Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
@en
Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
@nl
P2093
P2860
P50
P3181
P1433
P1476
Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
@en
P2093
A Radu Aricescu
Bryan T MacDonald
Doryen Bubeck
E Yvonne Jones
Jian-Hua Mao
Wen-Xue Liang
P2860
P304
P3181
P356
10.1016/J.DEVCEL.2011.09.007
P407
P577
2011-11-15T00:00:00Z