Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope
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Max Bergmann lecture protein epitope mimetics in the age of structural vaccinologyRecent advances on the use of structural biology for the design of novel envelope immunogens of HIV-1Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry.Transplanting supersites of HIV-1 vulnerability.Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies.A High Throughput Protein Microarray Approach to Classify HIV Monoclonal Antibodies and Variant Antigens.Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers.Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.HIV-1 envelope glycoprotein immunogens to induce broadly neutralizing antibodies.DNA vaccine with discontinuous T-cell epitope insertions into HSP65 scaffold as a potential means to improve immunogenicity of multi-epitope Mycobacterium tuberculosis vaccine.How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design.Combining different design strategies for rational affinity maturation of the MICA-NKG2D interface.Immunologic Insights on the Membrane Proximal External Region: A Major Human Immunodeficiency Virus Type-1 Vaccine Target.Reorientation of the helix of the tryptophan-rich gp41W peptide from HIV-1 at interfaces.Multi-Envelope HIV-1 Vaccine Development: Two Targeted Immune Pathways, One Desired Protective Outcome.
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P2860
Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope
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2011 nî lūn-bûn
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2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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Structure-Based Design of a Pr ...... IV-1 gp41 Neutralizing Epitope
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Structure-Based Design of a Pr ...... IV-1 gp41 Neutralizing Epitope
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Structure-Based Design of a Pr ...... IV-1 gp41 Neutralizing Epitope
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Structure-Based Design of a Pr ...... IV-1 gp41 Neutralizing Epitope
@ast
Structure-Based Design of a Pr ...... IV-1 gp41 Neutralizing Epitope
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Structure-Based Design of a Pr ...... IV-1 gp41 Neutralizing Epitope
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Structure-Based Design of a Pr ...... IV-1 gp41 Neutralizing Epitope
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Structure-Based Design of a Pr ...... IV-1 gp41 Neutralizing Epitope
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Structure-Based Design of a Pr ...... IV-1 gp41 Neutralizing Epitope
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Structure-Based Design of a Pr ...... IV-1 gp41 Neutralizing Epitope
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Michael B Zwick
Robert Pejchal
Robyn L Stanfield
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10.1016/J.JMB.2011.10.014
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2011-12-02T00:00:00Z