Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini - Wikidata - thesis-toulmin - TriplyDB

Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini

Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini

http://www.wikidata.org/entity/Q27675460

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HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing Structural insights into HDAC6 tubulin deacetylation and its selective inhibition Principles of Virus Uncoating: Cues and the Snooker Ball Ubiquitin in Influenza Virus Entry and Innate Immunity Virology. Unanchored ubiquitin in virus uncoating Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives The UBR-box and its relationship to binuclear RING-like treble clef zinc fingers Aggresome formation is regulated by RanBPM through an interaction with HDAC6 Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex Distal renal tubules are deficient in aggresome formation and autophagy upon aldosterone administration.Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking.Misfolded proteins: from little villains to little helpers in the fight against cancer.Versatile roles of k63-linked ubiquitin chains in trafficking.Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62.Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance Vimentin filament organization and stress sensing depend on its single cysteine residue and zinc binding.The HDAC6/APOBEC3G complex regulates HIV-1 infectiveness by inducing Vif autophagic degradation.Basal and stress-induced Hsp70 are modulated by ataxin-3.CDC48 function during TMV infection: regulation of virus movement and replication by degradation?Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells.Ataxin-3 and its e3 partners: implications for machado-joseph disease.Cdc48: a swiss army knife of cell biology.The autosomal dominant spinocerebellar ataxias: emerging mechanistic themes suggest pervasive Purkinje cell vulnerability.Histone deacetylase 6 in health and disease.Mass spectrometry insights into a tandem ubiquitin-binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin.N-terminal truncations of human bHLH transcription factor Twist1 leads to the formation of aggresomes.Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy A proof-of-concept study in engineering synthetic protein for selective recognition of substrate-free polyubiquitin.Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells.Restricted access: spatial sequestration of damaged proteins during stress and aging.Centrosomes at M phase act as a scaffold for the accumulation of intracellular ubiquitinated proteins.SUMO-1 is associated with a subset of lysosomes in glial protein aggregate diseases.Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease.Dynamic ubiquitin signaling in cell cycle regulation.Molecular dynamics of zinc-finger ubiquitin binding domains: a comparative study of histone deacetylase 6 and ubiquitin-specific protease 5.Inhibition of Proteasome Activity Induces Aggregation of IFIT2 in the Centrosome and Enhances IFIT2-Induced Cell Apoptosis.

P2860

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P2860

Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini

http://www.wikidata.org/entity/Q27675460

description

2012 nî lūn-bûn

@nan

2012 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2012年の論文

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2012年論文

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2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Protein Aggregates Are Recruit ...... Unanchored Ubiquitin C Termini

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Protein Aggregates Are Recruit ...... Unanchored Ubiquitin C Termini

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Protein Aggregates Are Recruit ...... Unanchored Ubiquitin C Termini

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type

label

Protein Aggregates Are Recruit ...... Unanchored Ubiquitin C Termini

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Protein Aggregates Are Recruit ...... Unanchored Ubiquitin C Termini

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Protein Aggregates Are Recruit ...... Unanchored Ubiquitin C Termini

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Protein Aggregates Are Recruit ...... Unanchored Ubiquitin C Termini

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Protein Aggregates Are Recruit ...... Unanchored Ubiquitin C Termini

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Protein Aggregates Are Recruit ...... Unanchored Ubiquitin C Termini

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JBC.M111.273730

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Journal of Biological Chemistry

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Protein Aggregates Are Recruit ...... Unanchored Ubiquitin C Termini

@en

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Aiping Dong

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Farrell MacKenzie

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Hui Ouyang

http://www.w3.org/2001/XMLSchema#string

Mani Ravichandran

http://www.w3.org/2001/XMLSchema#string

R Grace Zhai

http://www.w3.org/2001/XMLSchema#string

Wei Qiu

http://www.w3.org/2001/XMLSchema#string

Yousuf O Ali

http://www.w3.org/2001/XMLSchema#string

P2860

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin

Coot: model-building tools for molecular graphics

Ubiquitin-dependent protein degradation

The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin.

Breaking the chains: structure and function of the deubiquitinases

Aggresome formation and neurodegenerative diseases: therapeutic implications

Aggresomes: a cellular response to misfolded proteins

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

HDAC6-p97/VCP controlled polyubiquitin chain turnover

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2317-27

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scholarly article

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2828541

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10.1074/JBC.M111.273730

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4

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287

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Sirano Dhe-Paganon

Cheryl Arrowsmith

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2012-01-20T00:00:00Z

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22069321

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3268394

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