Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site
about
CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feastThe architecture of the spliceosomal U4/U6.U5 tri-snRNP.A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 proteinStructure of a yeast spliceosome at 3.6-angstrom resolutionThe 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysisCryo-EM structure of the spliceosome immediately after branchingPrp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.Mutations in spliceosomal proteins and retina degenerationBrr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding.Mutations in Splicing Factor Genes Are a Major Cause of Autosomal Dominant Retinitis Pigmentosa in Belgian FamiliesThe pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase ActivitySubstrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase.RNA and Proteins: Mutual Respect.Structural studies of the spliceosome: zooming into the heart of the machine.Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans.Re-refinement of the spliceosomal U4 snRNP core-domain structure.Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution.Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.Cajal bodies and snRNPs - friends with benefits.Functions and regulation of the Brr2 RNA helicase during splicing.Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures.Understanding pre-mRNA splicing through crystallography.Structure of the DEAH/RHA ATPase Prp43p bound to RNA implicates a pair of hairpins and motif Va in translocation along RNA.Crystallization and biochemical characterization of the human spliceosomal Aar2-Prp8(RNaseH) complex.The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation.A protein map of the yeast activated spliceosome as obtained by electron microscopyBrr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase.Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex.PRPF4 mutations cause autosomal dominant retinitis pigmentosa.Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.Domestication of self-splicing introns during eukaryogenesis: the rise of the complex spliceosomal machinery.Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine.Structure of a human catalytic step I spliceosome.Variability in clinical phenotypes of PRPF8-linked autosomal dominant retinitis pigmentosa correlates with differential PRPF8/SNRNP200 interactions.Mechanistic insights into precursor messenger RNA splicing by the spliceosome.Structural and functional analyses of the spliceosome requires a multi-disciplinary approach.
P2860
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P2860
Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structural Basis of Brr2-Prp8 ...... nd the Spliceosome Active Site
@ast
Structural Basis of Brr2-Prp8 ...... nd the Spliceosome Active Site
@en
Structural Basis of Brr2-Prp8 ...... nd the Spliceosome Active Site
@nl
type
label
Structural Basis of Brr2-Prp8 ...... nd the Spliceosome Active Site
@ast
Structural Basis of Brr2-Prp8 ...... nd the Spliceosome Active Site
@en
Structural Basis of Brr2-Prp8 ...... nd the Spliceosome Active Site
@nl
prefLabel
Structural Basis of Brr2-Prp8 ...... nd the Spliceosome Active Site
@ast
Structural Basis of Brr2-Prp8 ...... nd the Spliceosome Active Site
@en
Structural Basis of Brr2-Prp8 ...... nd the Spliceosome Active Site
@nl
P2093
P2860
P921
P3181
P1433
P1476
Structural Basis of Brr2-Prp8 ...... nd the Spliceosome Active Site
@en
P2093
Andrew J Newman
Hiroyuki Oshikane
Kiyoshi Nagai
Thi Hoang Duong Nguyen
Wojciech P Galej
P2860
P304
P3181
P356
10.1016/J.STR.2013.04.017
P577
2013-06-04T00:00:00Z