Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein - Wikidata - thesis-toulmin - TriplyDB

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

http://www.wikidata.org/entity/Q27678471

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The choreography of HIV-1 proteolytic processing and virion assembly Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution Monitoring binding of HIV-1 capsid assembly inhibitors using (19)F ligand-and (15)N protein-based NMR and X-ray crystallography: early hit validation of a benzodiazepine series Large-scale functional purification of recombinant HIV-1 capsid Characterization of the mode of action of a potent dengue virus capsid inhibitor Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor Production and purification of polymerization-competent HIV-1 capsid protein p24 (CA) in NiCo21(DE3) Escherichia coli.Identification and characterization of a novel HIV-1 nucleotide-competing reverse transcriptase inhibitor series.A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid Extreme genetic fragility of the HIV-1 capsid.Crystal structure of an antiviral ankyrin targeting the HIV-1 capsid and molecular modeling of the ankyrin-capsid complex.Microplate-based assay for identifying small molecules that bind a specific intersubunit interface within the assembled HIV-1 capsid.HIV-1 Gag as an Antiviral Target: Development of Assembly and Maturation Inhibitors.A Cell Internalizing Antibody Targeting Capsid Protein (p24) Inhibits the Replication of HIV-1 in T Cells Lines and PBMCs: A Proof of Concept Study.Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer.Functionalized Benzimidazole Scaffolds: Privileged Heterocycle for Drug Design in Therapeutic Medicine.HIV-1 Capsid Inhibitors as Antiretroviral Agents Host-rabies virus protein-protein interactions as druggable antiviral targets Integrating the HIV-1 assembly/maturation pathway.HIV-1 uncoating: connection to nuclear entry and regulation by host proteins.Allosteric modulation of protein oligomerization: an emerging approach to drug design.HIV-1 assembly, release and maturation.Comparison of Biochemical Properties of HIV-1 and HIV-2 Capsid Proteins.The small-molecule 3G11 inhibits HIV-1 reverse transcription.The NTD-CTD intersubunit interface plays a critical role in assembly and stabilization of the HIV-1 capsid.Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid Effects of Inner Nuclear Membrane Proteins SUN1/UNC-84A and SUN2/UNC-84B on the Early Steps of HIV-1 Infection.Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74.Functional conservation of HIV-1 Gag: implications for rational drug design.A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallization via compound-mediated dimerization.Inhibitors of the HIV-1 capsid, a target of opportunity.Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action

P2860

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P2860

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

http://www.wikidata.org/entity/Q27678471

description

2012 nî lūn-bûn

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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2012 թվականի հունիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Distinct Effects of Two HIV-1 ...... Domain of the Viral CA Protein

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Distinct Effects of Two HIV-1 ...... Domain of the Viral CA Protein

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Distinct Effects of Two HIV-1 ...... Domain of the Viral CA Protein

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Distinct Effects of Two HIV-1 ...... Domain of the Viral CA Protein

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Distinct Effects of Two HIV-1 ...... Domain of the Viral CA Protein

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Distinct Effects of Two HIV-1 ...... Domain of the Viral CA Protein

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Distinct Effects of Two HIV-1 ...... Domain of the Viral CA Protein

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Journal of Virology

P1476

Distinct Effects of Two HIV-1 ...... Domain of the Viral CA Protein

@en

P2093

Alexandre Gagnon

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Bruno Simoneau

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Christiane Yoakim

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Christopher T Lemke

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Elizabeth Wardrop

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Jean Rancourt

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Jean-François Mercier

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Lee Fader

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Martin Tremblay

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Nathalie Goudreau

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P2860

Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution

Domain-swapped dimerization of the HIV-1 capsid C-terminal domain

Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein

Structure of full-length HIV-1 CA: a model for the mature capsid lattice

Residues in the HIV-1 capsid assembly inhibitor binding site are essential for maintaining the assembly-competent quaternary structure of the capsid protein

X-ray structures of the hexameric building block of the HIV capsid.

Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

Atomic-level modelling of the HIV capsid

Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid

P304

6643-55

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scholarly article

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10.1128/JVI.00493-12

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12

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P478

86

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P50

Anne-Marie Faucher

Jacques Archambault

P577

2012-06-01T00:00:00Z

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P698

22496222

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3393593

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