Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA
about
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.Cytosolic Innate Immune Sensing and Signaling upon InfectionSTING: infection, inflammation and cancerThe Next Hurdle in Cancer Immunotherapy: Overcoming the Non-T-Cell-Inflamed Tumor MicroenvironmentThe STING pathway and the T cell-inflamed tumor microenvironmentCyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced OligomerizationNew insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of CancerInternational Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and diseaseRat and human STINGs profile similarly towards anticancer/antiviral compoundsNew perspectives on type I IFNs in cancerCharacterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging AlphavirusesNonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.Casein kinase II controls TBK1/IRF3 activation in IFN response against viral infection.Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STINGStructure-guided reprogramming of human cGAS dinucleotide linkage specificity.Cyclic GMP-AMP displays mucosal adjuvant activity in miceThe DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-β during Chlamydia trachomatis infection.Advancing host-directed therapy for tuberculosis.Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.Unabated adenovirus replication following activation of the cGAS/STING-dependent antiviral response in human cells.The mechanism of double-stranded DNA sensing through the cGAS-STING pathwayModified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathwayBinding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.Structural biology of innate immunity.OASes and STING: adaptive evolution in concertUV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo.Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers.Elucidating Complicated Assembling Systems in Biology Using Size-and-Shape Analysis of Sedimentation Velocity Data.STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade.Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.Inhibition of cGAS DNA Sensing by a Herpesvirus Virion ProteinOn the accuracy of unit-cell parameters in protein crystallography.Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome.Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production.Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response.Beyond autophagy: New roles for ULK1 in immune signaling and interferon responses.Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
P2860
Q24338728-0CC85BDE-2B7F-4D48-84EE-1A8DA1E04CAFQ26751063-E099CF78-367A-4A43-B7FC-9131A32D6D5BQ26776009-2CB71E73-3D3B-487D-92E8-13BB37570B12Q26796305-AC143E6C-9ADE-43AF-AE19-55AF17548954Q27008371-EB84A207-D59E-45E1-B3BD-ADE2E0468662Q27680866-8E0D2F26-EB4D-4006-9236-DA7617C31F66Q27701736-BCACA399-D41B-473C-A045-4B5F5013BB28Q28080773-005ABD10-C1F5-463B-96C6-1FE60181429EQ28081406-C5124E1A-29B5-46ED-9C5A-8C0C67ABC7C4Q28118888-C1818504-4703-4652-9590-6ABE9D08C041Q28256099-1D8B66DD-8678-4A27-BA54-71F0CB94D210Q28551420-3A7A483F-B7FB-4C51-A38B-34D6D930233BQ29871114-391B7632-BD32-4CF3-A413-82CBAFF7F1F7Q30373058-3CA7D334-F544-4C4A-91A3-1254AB8BBBFBQ33983673-CB34B8CC-3A14-4F73-A02B-A09EE668478AQ34148968-B7EE3414-DB2C-409B-B2F2-F90632239EA0Q34309082-74566453-FC8F-466B-AEB3-D284239B526AQ34419467-FAF77F0D-5BC6-4676-BD1B-85153588F1F7Q34466861-BEBC5F31-1AA5-4886-ACD1-8BF59004FE00Q34514089-7961617D-A438-4091-8914-D15AA0778DBEQ34594959-76687A55-52EE-4B93-AEF0-8B9908788295Q34624278-513330C3-31E9-4848-98F9-8A37D4444077Q35151746-40554CB0-80DB-45CE-A128-0DB60B33C391Q35238345-816C4AD2-574D-4D3B-B78D-131524760988Q35374728-DBCDAA57-6BDF-4606-B3CB-2CDF1E7DE6E2Q35569805-CC76F91D-EE81-4B8D-B231-32B24A474445Q35583137-69548194-23DB-4CA2-841F-6C10736880B8Q35595683-53ACE081-7F9F-4C8B-BE80-DFFD4064D7BCQ35634752-AEFC0B55-CC96-4DFD-B20A-44E608C9F140Q35661586-FE72BC2F-9B7A-4F83-806B-CB9069B0ECA5Q35790011-28509468-3FC6-4021-921C-D0C876FDCC53Q35858368-E2B75140-EEF6-4268-83D7-3F5964199687Q35895670-8D97F504-CDB0-4EB9-87D7-20B6F661711DQ36052710-259E35A3-33BB-4BDE-91F5-0FDD971046B2Q36244382-21162C3A-DCA7-4345-AD33-2D9F5EDF0EEEQ36435199-674E4199-FA0E-4DB7-A02B-E229E3CFA9B6Q36447597-0769EA1C-7B2A-4C75-84EB-D2F4A532CA87Q36453386-43D902D1-49E8-4C94-A67D-FAC35397DC8EQ36984702-CF3EF96F-DC7D-44EF-9C70-C679A8617557Q37021757-A45B1C40-90E2-471D-B2E9-E9058B0BDD8A
P2860
Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA
description
2013 nî lūn-bûn
@nan
2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structure-Function Analysis of ...... d Targeting by Antiviral DMXAA
@ast
Structure-Function Analysis of ...... d Targeting by Antiviral DMXAA
@en
Structure-Function Analysis of ...... d Targeting by Antiviral DMXAA
@nl
type
label
Structure-Function Analysis of ...... d Targeting by Antiviral DMXAA
@ast
Structure-Function Analysis of ...... d Targeting by Antiviral DMXAA
@en
Structure-Function Analysis of ...... d Targeting by Antiviral DMXAA
@nl
prefLabel
Structure-Function Analysis of ...... d Targeting by Antiviral DMXAA
@ast
Structure-Function Analysis of ...... d Targeting by Antiviral DMXAA
@en
Structure-Function Analysis of ...... d Targeting by Antiviral DMXAA
@nl
P2093
P2860
P50
P921
P3181
P1433
P1476
Structure-Function Analysis of ...... d Targeting by Antiviral DMXAA
@en
P2093
Artem A Serganov
Barbara L Gaffney
Liang Deng
Manuel Ascano
Peihong Dai
Roger A Jones
Stewart Shuman
Thomas Zillinger
Weiyi Wang
P2860
P304
P3181
P356
10.1016/J.CELL.2013.07.023
P407
P577
2013-08-15T00:00:00Z