Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1
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p38 MAPK in cardioprotection - are we there yet?Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formationCo-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tailThe p38β mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the α-G helix and MAPK insert.The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells.Cardiac myosin-binding protein C: a potential early biomarker of myocardial injury.Model Predicts That MKP1 and TAB1 Regulate p38α Nuclear Pulse and Its Basal Activity through Positive and Negative Feedback Loops in Response to IL-1.Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes.Intrinsically active variants of Erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of TEY phosphorylationTighter αC-helix-αL16-helix interactions seem to make p38α less prone to activation by autophosphorylation than Hog1.TAK1 selective inhibition: state of the art and future opportunities.Integration of endothelial protease-activated receptor-1 inflammatory signaling by ubiquitin.Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist.The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells.Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases.Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3.Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screensSsp2 Binding Activates the Smk1 Mitogen-Activated Protein Kinase.Quantifying the Release of Biomarkers of Myocardial Necrosis from Cardiac Myocytes and Intact Myocardium.TAB1-induced auto-activation of p38α mitogen-activated protein kinase is crucially dependent on Threonine 185.Autophosphorylation Affects Substrate-Binding Affinity of Tobacco Ca2+-Dependent Protein Kinase1.The E3 ubiquitin ligase Itch inhibits p38α signaling and skin inflammation through the ubiquitylation of Tab1.Insights of Crosstalk between p53 Protein and the MKK3/MKK6/p38 MAPK Signaling Pathway in Cancer.Autophosphorylation of Ser-6 via an intermolecular mechanism is important for the rapid reduction of NtCDPK1 kinase activity for substrate RSG.The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules
P2860
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P2860
Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1
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2013 nî lūn-bûn
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2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
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name
Mechanism and consequence of t ...... rotein kinase promoted by TAB1
@ast
Mechanism and consequence of t ...... rotein kinase promoted by TAB1
@en
Mechanism and consequence of t ...... rotein kinase promoted by TAB1
@nl
type
label
Mechanism and consequence of t ...... rotein kinase promoted by TAB1
@ast
Mechanism and consequence of t ...... rotein kinase promoted by TAB1
@en
Mechanism and consequence of t ...... rotein kinase promoted by TAB1
@nl
prefLabel
Mechanism and consequence of t ...... rotein kinase promoted by TAB1
@ast
Mechanism and consequence of t ...... rotein kinase promoted by TAB1
@en
Mechanism and consequence of t ...... rotein kinase promoted by TAB1
@nl
P2093
P2860
P50
P3181
P356
P1476
Mechanism and consequence of t ...... rotein kinase promoted by TAB1
@en
P2093
Apirat Chaikuad
Eva Denise Martin
Gian Felice DeNicola
Rekha Bassi
Renée Tata
Sharwari Verma
P2860
P2888
P304
P3181
P356
10.1038/NSMB.2668
P577
2013-09-15T00:00:00Z
P5875
P6179
1046582304