Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS - Wikidata - thesis-toulmin - TriplyDB

Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS

Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS

http://www.wikidata.org/entity/Q27680903

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A comprehensive review of amyotrophic lateral sclerosis Parsing Disease-relevant Protein Modifications from Epiphenomena: Perspective on the Structural Basis of SOD1-Mediated ALS.Kinetic Monte Carlo simulations of the assembly of filamentous biomacromolecules by dimer addition mechanism.Superoxide dismutases and superoxide reductases.Structural and kinetic analysis of protein-aggregate strains in vivo using binary epitope mapping Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model SOD1 aggregation in ALS mice shows simplistic test tube behavior.S-Nitrosoglutathione Reductase Plays Opposite Roles in SH-SY5Y Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis Uncovering the Mechanism of Aggregation of Human Transthyretin.A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation.Examination of Ataxin-3 (atx-3) Aggregation by Structural Mass Spectrometry Techniques: A Rationale for Expedited Aggregation upon Polyglutamine (polyQ) Expansion.Dynamic properties of SOD1 mutants can predict survival time of patients carrying familial amyotrophic lateral sclerosis.Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells.Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity.Protein charge ladders reveal that the net charge of ALS-linked superoxide dismutase can be different in sign and magnitude from predicted values.Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS).Target Intestinal Microbiota to Alleviate Disease Progression in Amyotrophic Lateral Sclerosis.Pathological hydrogen peroxide triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111.Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding.Cysteine to Serine Conversion at 111th Position Renders the Disaggregation and Retains the Stabilization of Detrimental SOD1 A4V Mutant Against Amyotrophic Lateral Sclerosis in Human-A Discrete Molecular Dynamics Study.A computational combinatorial approach identifies a protein inhibitor of superoxide dismutase 1 misfolding, aggregation, and cytotoxicity.MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: implications for familial ALS.Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations.Epigenetic Mechanisms of Gene Regulation in Amyotrophic Lateral Sclerosis.X-Ray Structural Study of Amyloid-Like Fibrils of Tau Peptides Bound to Small-Molecule Ligands.Poloxamer 188 decreases membrane toxicity of mutant SOD1 and ameliorates pathology observed in SOD1 mouse model for ALS.Evaluation of variability in high-resolution protein structures by global distance scoring.Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells Large SOD1 aggregates, unlike trimeric SOD1, do not impact cell viability in a model of amyotrophic lateral sclerosis Inhibitory effect of hydrophobic fullerenes on the β-sheet-rich oligomers of a hydrophilic GNNQQNY peptide revealed by atomistic simulations Amyloid assembly and disassembly

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Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS

http://www.wikidata.org/entity/Q27680903

description

2014 nî lūn-bûn

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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2014 թվականի հունվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Aggregation-triggering segment ...... for familial and sporadic ALS

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Aggregation-triggering segment ...... for familial and sporadic ALS

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Aggregation-triggering segment ...... for familial and sporadic ALS

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type

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Aggregation-triggering segment ...... for familial and sporadic ALS

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Aggregation-triggering segment ...... for familial and sporadic ALS

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Aggregation-triggering segment ...... for familial and sporadic ALS

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prefLabel

Aggregation-triggering segment ...... for familial and sporadic ALS

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Aggregation-triggering segment ...... for familial and sporadic ALS

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Aggregation-triggering segment ...... for familial and sporadic ALS

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PNAS.1320786110

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Proceedings of the National Academy of Sciences of the United States of America

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Aggregation-triggering segment ...... for familial and sporadic ALS

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Ahmad Galaleldeen

http://www.w3.org/2001/XMLSchema#string

David S Eisenberg

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Duane D Winkler

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Elizabeth L Guenther

http://www.w3.org/2001/XMLSchema#string

Lisa M Johnson

http://www.w3.org/2001/XMLSchema#string

Magdalena I Ivanova

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Michael R Sawaya

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P John Hart

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Stuart A Sievers

http://www.w3.org/2001/XMLSchema#string

P2860

Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis

Molecular basis for insulin fibril assembly

Atomic structures of amyloid cross-beta spines reveal varied steric zippers

Disrupted Zinc-Binding Sites in Structures of Pathogenic SOD1 Variants D124V and H80R

Determination and analysis of the 2 A-structure of copper, zinc superoxide dismutase

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

Amyotrophic lateral sclerosis

Mutation-dependent polymorphism of Cu,Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis.

Identifying the amylome, proteins capable of forming amyloid-like fibrils

Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis.

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10.1073/PNAS.1320786110

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1

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111

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259350680

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24344300

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amyotrophic lateral sclerosis

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