Structure of an HIV-1-neutralizing antibody target, the lipid-bound gp41 envelope membrane proximal region trimer
about
Systematic solution to homo-oligomeric structures determined by NMR.An algorithm to enumerate all possible protein conformations verifying a set of distance constraintsParallel Computational Protein Design.Lytic Inactivation of Human Immunodeficiency Virus by Dual Engagement of gp120 and gp41 Domains in the Virus Env Protein Trimer.Chemically modified peptides based on the membrane-proximal external region of the HIV-1 envelope induce high-titer, epitope-specific nonneutralizing antibodies in rabbitsA fusion intermediate gp41 immunogen elicits neutralizing antibodies to HIV-1Synergy in monoclonal antibody neutralization of HIV-1 pseudoviruses and infectious molecular clones.Conditional trimerization and lytic activity of HIV-1 gp41 variants containing the membrane-associated segments.Complete dissociation of the HIV-1 gp41 ectodomain and membrane proximal regions upon phospholipid bindingMembrane-Active Sequences within gp41 Membrane Proximal External Region (MPER) Modulate MPER-Containing Peptidyl Fusion Inhibitor Activity and the Biosynthesis of HIV-1 Structural ProteinsBiophysical Characterization of a Vaccine Candidate against HIV-1: The Transmembrane and Membrane Proximal Domains of HIV-1 gp41 as a Maltose Binding Protein FusionThe Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External RegionThe membrane proximal external regions of gp41 from HIV-1 strains HXB2 and JRFL have different sensitivities to alanine mutation.An immunogen containing four tandem 10E8 epitope repeats with exposed key residues induces antibodies that neutralize HIV-1 and activates an ADCC reporter geneEvaluation of a novel multi-immunogen vaccine strategy for targeting 4E10/10E8 neutralizing epitopes on HIV-1 gp41 membrane proximal external region.Deuterated detergents for structural and functional studies of membrane proteins: Properties, chemical synthesis and applications.Algorithms for protein design.HIV-1 antibodies and vaccine antigen selectively interact with lipid domains.Anti-MPER antibodies with heterogeneous neutralization capacity are detectable in most untreated HIV-1 infected individuals.
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P2860
Structure of an HIV-1-neutralizing antibody target, the lipid-bound gp41 envelope membrane proximal region trimer
description
2014 nî lūn-bûn
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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
@zh-hk
2014年論文
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2014年論文
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2014年论文
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name
Structure of an HIV-1-neutrali ...... embrane proximal region trimer
@ast
Structure of an HIV-1-neutrali ...... embrane proximal region trimer
@en
Structure of an HIV-1-neutrali ...... embrane proximal region trimer
@nl
type
label
Structure of an HIV-1-neutrali ...... embrane proximal region trimer
@ast
Structure of an HIV-1-neutrali ...... embrane proximal region trimer
@en
Structure of an HIV-1-neutrali ...... embrane proximal region trimer
@nl
prefLabel
Structure of an HIV-1-neutrali ...... embrane proximal region trimer
@ast
Structure of an HIV-1-neutrali ...... embrane proximal region trimer
@en
Structure of an HIV-1-neutrali ...... embrane proximal region trimer
@nl
P2093
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P3181
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P1476
Structure of an HIV-1-neutrali ...... embrane proximal region trimer
@en
P2093
Bruce R Donald
Harvey Sage
Jeffrey W Martin
Leonard D Spicer
Patrick N Reardon
S Moses Dennison
S Munir Alam
P2860
P304
P3181
P356
10.1073/PNAS.1309842111
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P577
2014-01-28T00:00:00Z