Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
about
Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasomeSubstrate specificity of the ubiquitin and Ubl proteasesDeubiquitinating enzymes in cellular signaling and disease regulationTargeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cellsCrystal structure of the human COP9 signalosomeMolecular architecture of the 40S⋅eIF1⋅eIF3 translation initiation complexDisassembly of Lys11 and mixed linkage polyubiquitin conjugates provides insights into function of proteasomal deubiquitinases Rpn11 and Ubp6.Proteasome assemblyStructural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimerSolution structure of yeast Rpn9: insights into proteasome lid assemblyNanobodies as Probes for Protein Dynamics in Vitro and in Cells.Nanobodies to Study G Protein-Coupled Receptor Structure and Function.Base-CP proteasome can serve as a platform for stepwise lid formationSubstrate degradation by the proteasome: a single-molecule kinetic analysis.Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to TumorigenesisGates, Channels, and Switches: Elements of the Proteasome MachineStructural characterization of the interaction of Ubp6 with the 26S proteasome.Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21Substrate Ubiquitination Controls the Unfolding Ability of the Proteasome.Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.Structure of an endogenous yeast 26S proteasome reveals two major conformational statesUSP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites.Structure of the human 26S proteasome at a resolution of 3.9 Å.Structural basis for dynamic regulation of the human 26S proteasome.Emerging mechanistic insights into AAA complexes regulating proteasomal degradation.Deubiquitinases and the new therapeutic opportunities offered to cancer.Introduction to the Minireview Series on Modern Technologies for In-cell Biochemistry.Structural disorder and its role in proteasomal degradation.Tuning the proteasome to brighten the end of the journey.The devil is in the details: comparison between COP9 signalosome (CSN) and the LID of the 26S proteasome.Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit.Proteasome Structure and Assembly.Nanobodies As Tools to Understand, Diagnose, and Treat African Trypanosomiasis.Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cellsCapzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome.Structural biology: Corralling a protein-degradation regulator.Meddling with Fate: The Proteasomal Deubiquitinating Enzymes.
P2860
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P2860
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
description
2014 nî lūn-bûn
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2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
@ast
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
@en
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
@nl
type
label
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
@ast
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
@en
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
@nl
prefLabel
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
@ast
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
@en
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
@nl
P2093
P2860
P50
P3181
P356
P1476
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
@en
P2093
Andreas Bracher
Friedrich Förster
Ganesh Ramnath Pathare
Han-Jie Zhou
István Nagy
Wolfgang Baumeister
P2860
P304
P3181
P356
10.1073/PNAS.1400546111
P407
P577
2014-02-25T00:00:00Z