Structure of parkin reveals mechanisms for ubiquitin ligase activation
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Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65Ubiquitin is phosphorylated by PINK1 to activate parkinShort mitochondrial ARF triggers Parkin/PINK1-dependent mitophagyUbiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysisHexokinase activity is required for recruitment of parkin to depolarized mitochondriaAtaxin-3 is a multivalent ligand for the parkin Ubl domainTRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexesUbiquitin modificationsLinking F-box protein 7 and parkin to neuronal degeneration in Parkinson's disease (PD)Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and DiseaseUbiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatmentParkin Regulation and Neurodegenerative DisordersExpanding the ubiquitin code through post-translational modificationRegulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin LigasesRBR E3 ubiquitin ligases: new structures, new insights, new questionsThe three 'P's of mitophagy: PARKIN, PINK1, and post-translational modificationsPINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's diseaseParkin structure and functionPathologic and therapeutic implications for the cell biology of parkinSelf and nonself: how autophagy targets mitochondria and bacteriaParkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tetheringCell-permeable parkin proteins suppress Parkinson disease-associated phenotypes in cultured cells and animalsPhosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase ParkinActivation of the E3 ubiquitin ligase Parkin.Structure of the human Parkin ligase domain in an autoinhibited stateStructural basis for ligase-specific conjugation of linear ubiquitin chains by HOIPMechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3Molecular basis for specificity of the Met1-linked polyubiquitin signalTargeting Pink1-Parkin-mediated mitophagy for treating liver injuryParkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality controlPerilous journey: a tour of the ubiquitin-proteasome systemProbes of ubiquitin E3 ligases enable systematic dissection of parkin activationStructural insights into Parkin substrate lysine targeting from minimal Miro substratesPINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activityIncorporating modeling and simulations in undergraduate biophysical chemistry course to promote understanding of structure-dynamics-function relationships in proteins.Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation.Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation.Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1.
P2860
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P2860
Structure of parkin reveals mechanisms for ubiquitin ligase activation
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structure of parkin reveals mechanisms for ubiquitin ligase activation
@ast
Structure of parkin reveals mechanisms for ubiquitin ligase activation
@en
Structure of parkin reveals mechanisms for ubiquitin ligase activation
@nl
type
label
Structure of parkin reveals mechanisms for ubiquitin ligase activation
@ast
Structure of parkin reveals mechanisms for ubiquitin ligase activation
@en
Structure of parkin reveals mechanisms for ubiquitin ligase activation
@nl
prefLabel
Structure of parkin reveals mechanisms for ubiquitin ligase activation
@ast
Structure of parkin reveals mechanisms for ubiquitin ligase activation
@en
Structure of parkin reveals mechanisms for ubiquitin ligase activation
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Structure of parkin reveals mechanisms for ubiquitin ligase activation
@en
P2093
Bhushan Nagar
Jean-François Trempe
Jonathan Krett
Karl Grenier
Kathy Wong
Marie Ménade
Marjan Seirafi
Matthew Y Tang
Sameer Al-Abdul-Wahid
Véronique Sauvé
P2860
P304
P3181
P356
10.1126/SCIENCE.1237908
P407
P577
2013-06-21T00:00:00Z