Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action
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Characterization of a Plasmodium falciparum Orthologue of the Yeast Ubiquinone-Binding Protein, Coq10pParasites resistant to the antimalarial atovaquone fail to transmit by mosquitoesKnockdown of Broad-Complex Gene Expression of Bombyx mori by Oligopyrrole Carboxamides Enhances Silk ProductionLansoprazole is an antituberculous prodrug targeting cytochrome bc1.Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparumInhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapySaccharomyces cerevisiae-based mutational analysis of the bc1 complex Qo site residue 279 to study the trade-off between atovaquone resistance and function.Within-Host Selection of Drug Resistance in a Mouse Model of Repeated Incomplete Malaria Treatment: Comparison between Atovaquone and Pyrimethamine.Within-Host Selection of Drug Resistance in a Mouse Model Reveals Dose-Dependent Selection of Atovaquone Resistance MutationsGlobally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.Current therapies and future possibilities for drug development against liver-stage malaria.Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria.The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia.Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling.Adverse neuropsychiatric effects of antimalarial drugs.Human Mitochondrial Cytochrome b Variants Studied in Yeast: Not All Are Silent Polymorphisms.Antimalarial Drug Resistance: A Threat to Malaria Elimination.Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic.A global map of genetic diversity in Babesia microti reveals strong population structure and identifies variants associated with clinical relapse.Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinonesGene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent.A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance.Lack of mitochondrial MutS homolog 1 in Toxoplasma gondii disrupts maintenance and fidelity of mitochondrial DNA and reveals metabolic plasticity.Structural analysis of mitochondrial cytochrome bc1 complex with atovaquone bound reveals the molecular basis of antimalarial drug action.Synthesis, SAR, and Docking Studies Disclose 2-Arylfuran-1,4-naphthoquinones as In Vitro Antiplasmodial Hits.Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria.Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis.Chlorophyll a is the crucial redox sensor and transmembrane signal transmitter in the cytochrome b6f complex. Components and mechanisms of state transitions from the hydrophobic mismatch viewpoint.Rational Design of Highly Potent and Slow-Binding Cytochrome bc1 Inhibitor as Fungicide by Computational Substitution Optimization.X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery.Selection of cytochrome B mutants by putative PfNDH2 inhibitorsRepurposing of an old drug: In vitro and in vivo efficacies of buparvaquone against Echinococcus multilocularis
P2860
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P2860
Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Structural analysis of atovaqu ...... is of antimalarial drug action
@ast
Structural analysis of atovaqu ...... is of antimalarial drug action
@en
Structural analysis of atovaqu ...... is of antimalarial drug action
@nl
type
label
Structural analysis of atovaqu ...... is of antimalarial drug action
@ast
Structural analysis of atovaqu ...... is of antimalarial drug action
@en
Structural analysis of atovaqu ...... is of antimalarial drug action
@nl
prefLabel
Structural analysis of atovaqu ...... is of antimalarial drug action
@ast
Structural analysis of atovaqu ...... is of antimalarial drug action
@en
Structural analysis of atovaqu ...... is of antimalarial drug action
@nl
P2860
P3181
P356
P1476
Structural analysis of atovaqu ...... is of antimalarial drug action
@en
P2093
Dominic Birth
P2860
P2888
P3181
P356
10.1038/NCOMMS5029
P407
P577
2014-06-04T00:00:00Z
P5875
P6179
1027281151