Binding of cephalothin and cefotaxime to D-ala-D-ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum beta-lactamases
about
The complexed structure and antimicrobial activity of a non-β-lactam inhibitor of AmpC β-lactamaseA 1.2-A snapshot of the final step of bacterial cell wall biosynthesisAcyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillinHydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymesCrystal Structures of Covalent Complexes of β-Lactam Antibiotics with Escherichia coli Penicillin-Binding Protein 5: Toward an Understanding of Antibiotic SpecificityStructural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosaKinetic and Crystallographic Studies of Extended-Spectrum GES-11, GES-12, and GES-14 -LactamasesCrystal structure of D-stereospecific amidohydrolase from Streptomyces sp. 82F2 - insight into the structural factors for substrate specificityExploring the role of a conserved class A residue in the Ω-Loop of KPC-2 β-lactamase: a mechanism for ceftazidime hydrolysisAmino acid sequence determinants of extended spectrum cephalosporin hydrolysis by the class C P99 beta-lactamase.Identification of residues critical for catalysis in a class C beta-lactamase by combinatorial scanning mutagenesis.Substituted aryl malonamates as new serine beta-lactamase substrates: structure-activity studiesKinship and diversification of bacterial penicillin-binding proteins and beta-lactamases.Extended-spectrum and inhibitor-resistant TEM-type beta-lactamases: mutations, specificity, and three-dimensional structure.The 2-A postdoc.Specificity inversion of Ochrobactrum anthropi D-aminopeptidase to a D,D-carboxypeptidase with new penicillin binding activity by directed mutagenesis.Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime.Cephalosporin substrate specificity determinants of TEM-1 beta-lactamase.Natural evolution of TEM-1 β-lactamase: experimental reconstruction and clinical relevance.Structure-function studies of Ser-289 in the class C beta-lactamase from Enterobacter cloacae P99.Diversity of substitutions within or adjacent to conserved amino acid motifs of penicillin-binding protein 2X in cephalosporin-resistant Streptococcus pneumoniae isolates.Mutation in Serratia marcescens AmpC beta-lactamase producing high-level resistance to ceftazidime and cefpirome.Penicillin-binding proteins 2b and 2x of Streptococcus pneumoniae are primary resistance determinants for different classes of beta-lactam antibioticsA mutation in the D,D-carboxypeptidase penicillin-binding protein 3 of Streptococcus pneumoniae contributes to cefotaxime resistance of the laboratory mutant C604.Catalytic properties of class A beta-lactamases: efficiency and diversity.Cloning, expression, and characterization of a lipolytic enzyme gene (lip8) from Pseudomonas aeruginosa LST-03.pKa, MM, and QM studies of mechanisms of beta-lactamases and penicillin-binding proteins: acylation step.Crystal structure of the Actinomadura R39 DD-peptidase reveals new domains in penicillin-binding proteins.Effects on substrate profile by mutational substitutions at positions 164 and 179 of the class A TEM(pUC19) beta-lactamase from Escherichia coli.Optimization of a β-Lactam Scaffold for Antibacterial Activity via the Inhibition of Bacterial Type I Signal Peptidase.Mutations in the active site of penicillin-binding protein PBP2x from Streptococcus pneumoniae. Role in the specificity for beta-lactam antibiotics.
P2860
Q27620652-69D4B672-96D2-4F84-996F-E98A0DC98AFBQ27629448-FD650298-748C-41C2-AF14-F91D0268FBFDQ27639628-12FC3D3C-C9B6-49ED-BAF1-14612ABC0F6AQ27642738-31EB1705-3C4F-4481-8D00-5AFF7FBA0678Q27664109-08845F4A-AC75-4E5C-91C0-D24E572ADCCDQ27666204-F15A03D5-E4EC-4E04-B8EE-E27D12C3B83BQ27671606-55D9E41B-C272-41F3-B2EE-0295B8B116AEQ27702537-9B3C0A5C-E482-47EE-8296-E0BB1F0D7A01Q28272040-91B42544-EDFF-456E-946A-DF7454CD16FCQ30731622-C82D84DF-791E-47C5-8E07-1165A84F1509Q30968138-BF6CE55B-1910-4BB4-A3D5-D63F15CFB97EQ33638319-AA1CB509-3887-4A0C-BBD9-E75771CC73B2Q33690362-027D48C3-D500-4CFD-85E5-921EE40ABF35Q35120519-1B57F39D-C0BB-498D-AFCA-781DBB70ED35Q35914492-3B71ED3F-2403-4FDC-BC04-ADB34D65E231Q36477019-62630BCB-A3AE-44A2-B176-08D1826AA6E4Q36818729-B6D14AB2-CF8E-4432-8AC6-B9345F087E9EQ36889931-946A7667-0F3F-4F2C-A612-0201DF6712D0Q37735903-38481483-BE28-41C2-BB3C-7D1ECF78A573Q39470234-B0C1B857-1A29-44BD-A838-7E115493624AQ39470706-6284C45D-21C0-4595-A555-857855FB2E73Q39478020-45F01FD3-65D7-45B5-983C-E3F6A2814415Q39781766-06B5924F-03BE-484C-9987-A148B498F9E9Q39784064-1EBB5F11-B9B9-4689-8971-E0C360F5DDC8Q40863105-24647808-D444-4B23-9AF4-69DDB093184FQ42636529-18080BC9-37F3-4BA6-B5D2-65F162A295BBQ44190837-54B664D2-906F-4FE2-B82F-77FBFC4F8A06Q46575005-D57D0EA3-B134-4F9B-A16F-3AF135F857E8Q51646240-9C551388-AFEF-40DD-B334-5800657A4EB9Q52579064-40E5C6CF-2853-4FCD-9259-5F1BAC441ECCQ54658982-E7AA0671-4472-45BC-BD5B-924FD37C8F4D
P2860
Binding of cephalothin and cefotaxime to D-ala-D-ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum beta-lactamases
description
1995 nî lūn-bûn
@nan
1995 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Binding of cephalothin and cef ...... ended-spectrum beta-lactamases
@ast
Binding of cephalothin and cef ...... ended-spectrum beta-lactamases
@en
Binding of cephalothin and cef ...... ended-spectrum beta-lactamases
@nl
type
label
Binding of cephalothin and cef ...... ended-spectrum beta-lactamases
@ast
Binding of cephalothin and cef ...... ended-spectrum beta-lactamases
@en
Binding of cephalothin and cef ...... ended-spectrum beta-lactamases
@nl
prefLabel
Binding of cephalothin and cef ...... ended-spectrum beta-lactamases
@ast
Binding of cephalothin and cef ...... ended-spectrum beta-lactamases
@en
Binding of cephalothin and cef ...... ended-spectrum beta-lactamases
@nl
P2093
P356
P1433
P1476
Binding of cephalothin and cef ...... ended-spectrum beta-lactamases
@en
P2093
P304
P356
10.1021/BI00029A030
P407
P577
1995-07-25T00:00:00Z