Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy
about
Predicting internal protein dynamics from structures using coupled networks of hindered rotators.A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor.A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor alpha chainA potent human interleukin-4 antagonist stimulates the proliferation of murine cells expressing the human interleukin-4 binding chain.Different human interleukin-4 mutants preferentially activate human or murine common receptor gamma chain.Species-specific agonist/antagonist activities of human interleukin-4 variants suggest distinct ligand binding properties of human and murine common receptor gamma chain.Rational design of interleukin-21 antagonist through selective elimination of the gammaC binding epitope.Induced conformational change in human IL-4 upon binding of a signal-neutralizing DARPin.Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency.Antagonist design through forced electrostatic mismatch
P2860
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P2860
Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy
description
1994 nî lūn-bûn
@nan
1994 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1994年の論文
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1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
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name
Aspects of receptor binding an ...... tagenesis and NMR spectroscopy
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Aspects of receptor binding an ...... tagenesis and NMR spectroscopy
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Aspects of receptor binding an ...... tagenesis and NMR spectroscopy
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type
label
Aspects of receptor binding an ...... tagenesis and NMR spectroscopy
@ast
Aspects of receptor binding an ...... tagenesis and NMR spectroscopy
@en
Aspects of receptor binding an ...... tagenesis and NMR spectroscopy
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prefLabel
Aspects of receptor binding an ...... tagenesis and NMR spectroscopy
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Aspects of receptor binding an ...... tagenesis and NMR spectroscopy
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Aspects of receptor binding an ...... tagenesis and NMR spectroscopy
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P2093
P356
P1476
Aspects of receptor binding an ...... tagenesis and NMR spectroscopy
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P2093
P304
P356
10.1006/JMBI.1994.1245
P407
P577
1994-04-08T00:00:00Z