Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes
about
2-Aminopurine as a fluorescent probe for DNA base flipping by methyltransferasesStructure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNAProbing a rate-limiting step by mutational perturbation of AdoMet binding in the HhaI methyltransferaseZebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA MethyltransferasesStructure and mutagenesis of the DNA modification-dependent restriction endonuclease AspBHIStructure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNAStructure of pvu II DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignmentDNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferaseStructures of HhaI methyltransferase complexed with substrates containing mismatches at the target baseHuman DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanismConformations of an adenine bulge in a DNA octamer and its influence on DNA structure from molecular dynamics simulationsFacile synthesis of SAM-peptide conjugates through alkyl linkers targeting protein N-terminal methyltransferase 1Flexibility of the linker between the domains of DNA methyltransferase SsoII revealed by small-angle X-ray scattering: implications for transcription regulation in SsoII restriction-modification system.Investigating the target recognition of DNA cytosine-5 methyltransferase HhaI by library selection using in vitro compartmentalisation.Computation of DNA backbone conformations.Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine.AdoMet-dependent methylation, DNA methyltransferases and base flipping.Control of catalytic cycle by a pair of analogous tRNA modification enzymes.Low-frequency normal mode in DNA HhaI methyltransferase and motions of residues involved in the base flipping.Molecular and enzymatic profiles of mammalian DNA methyltransferases: structures and targets for drugs.Crystallization of the novel S-adenosyl-L-methionine-dependent C-methyltransferase CouO from Streptomyces rishiriensis and preliminary diffraction data analysisCoupling between catalytic loop motions and enzyme global dynamicsModification-dependent restriction endonuclease, MspJI, flips 5-methylcytosine out of the DNA helix.Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases.The mechanism of M.HhaI DNA C5 cytosine methyltransferase enzyme: a quantum mechanics/molecular mechanics approach.Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences.An overview of the analysis of DNA methylation in mammalian genomes.Crystallization and preliminary crystallographic analysis of the (cytosine-5)-DNA methyltransferase NlaX from Neisseria lactamica.Transducing methyltransferase activity into electrical signals in a carbon nanotube-DNA device().DNA cytosine methylation: structural and thermodynamic characterization of the epigenetic marking mechanism.DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site.DNA methyltransferases: mechanistic models derived from kinetic analysis.Water-assisted dual mode cofactor recognition by HhaI DNA methyltransferase.Bacteriophage T4 Dam DNA-[N6-adenine]methyltransferase. Kinetic evidence for a catalytically essential conformational change in the ternary complex.The mechanism of DNA cytosine-5 methylation. Kinetic and mutational dissection of Hhai methyltransferase.DNA bending induced by DNA (cytosine-5) methyltransferases.Reconciling structure and function in HhaI DNA cytosine-C-5 methyltransferase.Functional mapping of the EcoRV DNA methyltransferase by random mutagenesis and screening for catalytically inactive mutants.Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors.
P2860
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P2860
Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes
description
1996 nî lūn-bûn
@nan
1996 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Enzymatic C5-cytosine methylat ...... ansferase-DNA-AdoHcy complexes
@ast
Enzymatic C5-cytosine methylat ...... ansferase-DNA-AdoHcy complexes
@en
Enzymatic C5-cytosine methylat ...... ansferase-DNA-AdoHcy complexes
@nl
type
label
Enzymatic C5-cytosine methylat ...... ansferase-DNA-AdoHcy complexes
@ast
Enzymatic C5-cytosine methylat ...... ansferase-DNA-AdoHcy complexes
@en
Enzymatic C5-cytosine methylat ...... ansferase-DNA-AdoHcy complexes
@nl
prefLabel
Enzymatic C5-cytosine methylat ...... ansferase-DNA-AdoHcy complexes
@ast
Enzymatic C5-cytosine methylat ...... ansferase-DNA-AdoHcy complexes
@en
Enzymatic C5-cytosine methylat ...... ansferase-DNA-AdoHcy complexes
@nl
P2093
P356
P1476
Enzymatic C5-cytosine methylat ...... ansferase-DNA-AdoHcy complexes
@en
P2093
P304
P356
10.1006/JMBI.1996.0489
P407
P577
1996-09-06T00:00:00Z