Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity
about
Structure and function of type II restriction endonucleasesRetroviral intasome assembly and inhibition of DNA strand transferThe three-dimensional structure of a Tn5 transposase-related protein determined to 2.9-A resolutionA relaxed active site after exon ligation by the group I intronA Crystal Structure of the Catalytic Core Domain of an Avian Sarcoma and Leukemia Virus Integrase Suggests an Alternate Dimeric AssemblyStructure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitorThree new structures of the core domain of HIV-1 integrase: an active site that binds magnesiumStructural basis for inactivating mutations and pH-dependent activity of avian sarcoma virus integrasePurified Argonaute2 and an siRNA form recombinant human RISCStructural determinants of metal-induced conformational changes in HIV-1 integrase.In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate.Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linkingAn inhibitory monoclonal antibody binds at the turn of the helix-turn-helix motif in the N-terminal domain of HIV-1 integrase.Mapping the epitope of an inhibitory monoclonal antibody to the C-terminal DNA-binding domain of HIV-1 integrase.Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody.A dynamic model of HIV integrase inhibition and drug resistance.HIV-1 IN inhibitors: 2010 update and perspectivesUse of patient-derived human immunodeficiency virus type 1 integrases to identify a protein residue that affects target site selectionSolution conformation and dynamics of the HIV-1 integrase core domain.The same two monomers within a MuA tetramer provide the DDE domains for the strand cleavage and strand transfer steps of transposition.Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes.Structure-based HIV-1 integrase inhibitor design: a future perspective.Tn5 transposase active site mutations suggest position of donor backbone DNA in synaptic complex.Molecular dynamics studies of the wild-type and double mutant HIV-1 integrase complexed with the 5CITEP inhibitor: mechanism for inhibition and drug resistanceMetal binding by the D,DX35E motif of human immunodeficiency virus type 1 integrase: selective rescue of Cys substitutions by Mn2+ in vitroAn amino acid in the central catalytic domain of three retroviral integrases that affects target site selection in nonviral DNA.Single-particle image reconstruction of a tetramer of HIV integrase bound to DNA.Hybrid quantum mechanical/molecular mechanical molecular dynamics simulations of HIV-1 integrase/inhibitor complexes.Computer tools in the discovery of HIV-1 integrase inhibitorsRaltegravir: molecular basis of its mechanism of actionStructural biology of retroviral DNA integration.Structural and functional insights into foamy viral integraseFunctional analysis of N-terminal residues of ty1 integrase.Piecing together the structure of retroviral integrase, an important target in AIDS therapyHIV-1 Integrase-DNA Recognition Mechanisms.Retroviral integrase protein and intasome nucleoprotein complex structures.Design, synthesis, and antiviral evaluation of some 3'-carboxymethyl-3'-deoxyadenosine derivatives.HIV integrase inhibitor, Elvitegravir, impairs RAG functions and inhibits V(D)J recombination.Dihydroxythiophenes are novel potent inhibitors of human immunodeficiency virus integrase with a diketo acid-like pharmacophore.Inhibition of human immunodeficiency virus type 1 reverse transcriptase, RNase H, and integrase activities by hydroxytropolones.
P2860
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P2860
Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity
description
1997 nî lūn-bûn
@nan
1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Binding of different divalent ...... effects on enzymatic activity
@ast
Binding of different divalent ...... effects on enzymatic activity
@en
Binding of different divalent ...... effects on enzymatic activity
@nl
type
label
Binding of different divalent ...... effects on enzymatic activity
@ast
Binding of different divalent ...... effects on enzymatic activity
@en
Binding of different divalent ...... effects on enzymatic activity
@nl
prefLabel
Binding of different divalent ...... effects on enzymatic activity
@ast
Binding of different divalent ...... effects on enzymatic activity
@en
Binding of different divalent ...... effects on enzymatic activity
@nl
P2093
P2860
P356
P1476
Binding of different divalent ...... effects on enzymatic activity
@en
P2093
A M Skalka
A Wlodawer
J Alexandratos
P2860
P304
P356
10.1074/JBC.272.29.18161
P407
P577
1997-07-18T00:00:00Z