Genetic selection of peptide inhibitors of biological pathways.
about
The Golgi-associated protein GRASP65 regulates spindle dynamics and is essential for cell divisionA direct role for GRASP65 as a mitotically regulated Golgi stacking factorBringing estrogen receptors under control.The yeast orthologue of GRASP65 forms a complex with a coiled-coil protein that contributes to ER to Golgi trafficReversible transdominant inhibition of a metabolic pathway. In vivo evidence of interaction between two sequential tricarboxylic acid cycle enzymes in yeast.In vitro evolution of recognition specificity mediated by SH3 domains reveals target recognition rules.Designing specific protein-protein interactions using computation, experimental library screening, or integrated methodsA CDC6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor.Investigating and Engineering Enzymes by Genetic Selection.Production of cyclic peptides and proteins in vivoOligonucleotide-conjugated beads for transdominant genetic experimentsYarrowia lipolytica vesicle-mediated protein transport pathways.Genetic selection for modulators of a retinoic-acid-responsive reporter in human cellsDomain repertoires as a tool to derive protein recognition rules.Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells.Applications of display technology in protein analysis.Enrichment during transdominant genetic experiments using a flow sorter.Genetic selection for dissociative inhibitors of designated protein-protein interactions.Targeted modification and transportation of cellular proteins.Chemical genetics: ligand-based discovery of gene function.Convergent evolution with combinatorial peptides.A novel strategy to design binding molecules harnessing the modular nature of repeat proteins.Peptide aptamers: recent developments for cancer therapy.An antiproliferative genetic screening identifies a peptide aptamer that targets calcineurin and up-regulates its activity.Exploiting combinatorial cultivation conditions to infer transcriptional regulationIdentifying small-molecule modulators of protein-protein interactions.Construction and maintenance of randomized retroviral expression libraries for transmembrane protein engineering.Gene expression analysis as an aid to the identification of drug targets.Peptide-mediated broad-spectrum plant resistance to tospoviruses.Isolation of peptide aptamers that inhibit intracellular processes.Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein.Controlling small guanine-nucleotide-exchange factor function through cytoplasmic RNA intramers.Genetic Selection of Peptide Aptamers That Interact and Inhibit Both Small Protein B and Alternative Ribosome-Rescue Factor A of Aeromonas veronii C4.TEM-1 beta-lactamase as a scaffold for protein recognition and assayThe eleven-year switch of peptide aptamers.The cost of gene expression underlies a fitness trade-off in yeast.Nucleic acid and peptide aptamers: fundamentals and bioanalytical aspects.DNA microarrays: an overview of technologies and applications to toxicology.Drug target discovery using retroviruses.Aptamers and their potential to selectively target aspects of EGF, Wnt/β-catenin and TGFβ-smad family signaling.
P2860
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P2860
Genetic selection of peptide inhibitors of biological pathways.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Genetic selection of peptide inhibitors of biological pathways.
@ast
Genetic selection of peptide inhibitors of biological pathways.
@en
Genetic selection of peptide inhibitors of biological pathways.
@nl
type
label
Genetic selection of peptide inhibitors of biological pathways.
@ast
Genetic selection of peptide inhibitors of biological pathways.
@en
Genetic selection of peptide inhibitors of biological pathways.
@nl
prefLabel
Genetic selection of peptide inhibitors of biological pathways.
@ast
Genetic selection of peptide inhibitors of biological pathways.
@en
Genetic selection of peptide inhibitors of biological pathways.
@nl
P2093
P3181
P1433
P1476
Genetic selection of peptide inhibitors of biological pathways
@en
P2093
A W Murray
C J Roberts
S H Friend
S M O'Rourke
T C Norman
T R Hughes
P304
P3181
P356
10.1126/SCIENCE.285.5427.591
P407
P577
1999-07-01T00:00:00Z