Mrc1 transduces signals of DNA replication stress to activate Rad53.
about
An overview of Cdk1-controlled targets and processesHuman Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpointDisruption of mechanisms that prevent rereplication triggers a DNA damage responseLoss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damageHuman Claspin works with BRCA1 to both positively and negatively regulate cell proliferationCharacterization of functional domains in human ClaspinStabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility proteinMrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpointActivation of the DNA damage checkpoint in mutants defective in DNA replication initiationClaspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activationRegulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatinTipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint functionGerminating fission yeast spores delay in G1 in response to UV irradiationA network of multi-tasking proteins at the DNA replication fork preserves genome stabilityDNA polymerase ε and its roles in genome stabilitySurprising complexity of the Asf1 histone chaperone-Rad53 kinase interactionPhosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4TopBP1Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae.Activation of the S-phase checkpoint inhibits degradation of the F-box protein Dia2Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56.Esc4/Rtt107 and the control of recombination during replication.Elg1 forms an alternative RFC complex important for DNA replication and genome integrityUse of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.Genetic dissection of parallel sister-chromatid cohesion pathways.Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae.An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks.The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes.A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome.A role for Chd1 and Set2 in negatively regulating DNA replication in Saccharomyces cerevisiaeCmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control.SCF(Dia2) regulates DNA replication forks during S-phase in budding yeastGenetic analysis of Saccharomyces cerevisiae H2A serine 129 mutant suggests a functional relationship between H2A and the sister-chromatid cohesion partners Csm3-Tof1 for the repair of topoisomerase I-induced DNA damage.Loss of yeast peroxiredoxin Tsa1p induces genome instability through activation of the DNA damage checkpoint and elevation of dNTP levelsMrc1 and Tof1 regulate DNA replication forks in different ways during normal S phaseMrc1, Tof1 and Csm3 inhibit CAG.CTG repeat instability by at least two mechanisms.TOR signaling is a determinant of cell survival in response to DNA damage.An Eco1-independent sister chromatid cohesion establishment pathway in S. cerevisiae.S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.
P2860
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P2860
Mrc1 transduces signals of DNA replication stress to activate Rad53.
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
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2001年學術文章
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name
Mrc1 transduces signals of DNA replication stress to activate Rad53.
@ast
Mrc1 transduces signals of DNA replication stress to activate Rad53.
@en
Mrc1 transduces signals of DNA replication stress to activate Rad53.
@nl
type
label
Mrc1 transduces signals of DNA replication stress to activate Rad53.
@ast
Mrc1 transduces signals of DNA replication stress to activate Rad53.
@en
Mrc1 transduces signals of DNA replication stress to activate Rad53.
@nl
prefLabel
Mrc1 transduces signals of DNA replication stress to activate Rad53.
@ast
Mrc1 transduces signals of DNA replication stress to activate Rad53.
@en
Mrc1 transduces signals of DNA replication stress to activate Rad53.
@nl
P2093
P3181
P356
P1433
P1476
Mrc1 transduces signals of DNA replication stress to activate Rad53.
@en
P2093
A A Alcasabas
A J Osborn
J F Diffley
P J Werler
S J Elledge
P2888
P304
P3181
P356
10.1038/NCB1101-958
P407
P577
2001-11-01T00:00:00Z
P5875
P6179
1044091832