The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae.
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Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 bindingThe mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements.CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase.Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylaseHuman Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcriptionExonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNAConservation of the deadenylase activity of proteins of the Caf1 family in humanIdentification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding proteinThe structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complexUNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinantDepletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growthRepression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complexFoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complexComponents of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complexNOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domainMammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylationThe BTG2 protein is a general activator of mRNA deadenylationPoly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding proteinThe Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferationStructural basis for the antiproliferative activity of the Tob-hCaf1 complexThe Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescenceAn unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodiesNot1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolinCNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell deathComparative genomics and evolution of proteins involved in RNA metabolismThe mechanism and regulation of deadenylation: identification and characterization of Xenopus PARNHuman Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structuresYeast transcripts cleaved by an internal ribozyme provide new insight into the role of the cap and poly(A) tail in translation and mRNA decayTethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decayMechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylasesA genomic screen in yeast reveals novel aspects of nonstop mRNA metabolismHuman TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylationA multiplicity of coactivators is required by Gcn4p at individual promoters in vivoDNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex.The Ccr4-Not complex is a key regulator of eukaryotic gene expressionCcr4-Not complex: the control freak of eukaryotic cellsThe long and the short of it: the role of the zinc finger polyadenosine RNA binding protein, Nab2, in control of poly(A) tail lengthMechanisms of deadenylation-dependent decay
P2860
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P2860
The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae.
description
2001 nî lūn-bûn
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2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The transcription factor assoc ...... e in Saccharomyces cerevisiae.
@ast
The transcription factor assoc ...... e in Saccharomyces cerevisiae.
@en
The transcription factor assoc ...... e in Saccharomyces cerevisiae.
@nl
type
label
The transcription factor assoc ...... e in Saccharomyces cerevisiae.
@ast
The transcription factor assoc ...... e in Saccharomyces cerevisiae.
@en
The transcription factor assoc ...... e in Saccharomyces cerevisiae.
@nl
prefLabel
The transcription factor assoc ...... e in Saccharomyces cerevisiae.
@ast
The transcription factor assoc ...... e in Saccharomyces cerevisiae.
@en
The transcription factor assoc ...... e in Saccharomyces cerevisiae.
@nl
P2093
P3181
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P1476
The transcription factor assoc ...... e in Saccharomyces cerevisiae.
@en
P2093
M A Valencia-Sanchez
R R Staples
P304
P3181
P356
10.1016/S0092-8674(01)00225-2
P407
P577
2001-02-09T00:00:00Z