Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product
about
Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growthInfluence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-IRas-related GTPases and the cytoskeletonPurified yeast protein farnesyltransferase is structurally and functionally similar to its mammalian counterpart.RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins.The Saccharomyces cerevisiae prenylcysteine carboxyl methyltransferase Ste14p is in the endoplasmic reticulum membrane.Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity.Evidence for prenylation-dependent targeting of a Ykt6 SNARE in Plasmodium falciparumProtein farnesyltransferase and protein prenylation in Plasmodium falciparumDisruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cellsSite-directed mutations altering the CAAX box of Ste18, the yeast pheromone-response pathway G gamma subunit.Splice variants of SmgGDS control small GTPase prenylation and membrane localizationCell polarization directed by extracellular cues in yeast.Mutant farnesyltransferase beta subunit of Saccharomyces cerevisiae that can substitute for geranylgeranyltransferase type I beta subunit.Consequences of altered isoprenylation targets on a-factor export and bioactivity.Ras signaling in yeast.Spreading of differentiating human monocytes is associated with a major increase in membrane-bound CDC42.Identification of Ras farnesyltransferase inhibitors by microbial screening.Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.Genetic evidence for in vivo cross-specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiaeFunctional interaction between p21rap1A and components of the budding pathway in Saccharomyces cerevisiae.Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity.The Schizosaccharomyces pombe cwg2+ gene codes for the beta subunit of a geranylgeranyltransferase type I required for beta-glucan synthesis.Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.CSD2, CSD3, and CSD4, genes required for chitin synthesis in Saccharomyces cerevisiae: the CSD2 gene product is related to chitin synthases and to developmentally regulated proteins in Rhizobium species and Xenopus laevis.Endoproteolytic processing of a farnesylated peptide in vitro.Tetrapeptide inhibitors of protein farnesyltransferase: amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation.Farnesylcysteine, a constituent of the alpha and beta subunits of rabbit skeletal muscle phosphorylase kinase: localization by conversion to S-ethylcysteine and by tandem mass spectrometryRestricted substrate specificity for the geranylgeranyltransferase-I enzyme in Cryptococcus neoformans: implications for virulence.Control of RAS mRNA level by the mevalonate pathway.A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.Prenylation of Rho1p is required for activation of yeast 1, 3-beta-glucan synthase.Molecular characterization of the Caenorhabditis elegans Rho GDP-dissociation inhibitor.Polarity establishment by Cdc42: Key roles for positive feedback and differential mobility.Geranylgeranyltransferase I of Candida albicans: null mutants or enzyme inhibitors produce unexpected phenotypes.Suppression of yeast geranylgeranyl transferase I defect by alternative prenylation of two target GTPases, Rho1p and Cdc42p.A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors.Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe.
P2860
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P2860
Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product
description
1991 nî lūn-bûn
@nan
1991 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Protein geranylgeranyltransfer ...... but not the DPR1 gene product
@ast
Protein geranylgeranyltransfer ...... but not the DPR1 gene product
@en
Protein geranylgeranyltransfer ...... but not the DPR1 gene product.
@nl
type
label
Protein geranylgeranyltransfer ...... but not the DPR1 gene product
@ast
Protein geranylgeranyltransfer ...... but not the DPR1 gene product
@en
Protein geranylgeranyltransfer ...... but not the DPR1 gene product.
@nl
prefLabel
Protein geranylgeranyltransfer ...... but not the DPR1 gene product
@ast
Protein geranylgeranyltransfer ...... but not the DPR1 gene product
@en
Protein geranylgeranyltransfer ...... but not the DPR1 gene product.
@nl
P2093
P2860
P356
P1476
Protein geranylgeranyltransfer ...... but not the DPR1 gene product
@en
P2093
A A Finegold
C C Farnsworth
D I Johnson
J A Glomset
P2860
P304
P356
10.1073/PNAS.88.10.4448
P407
P577
1991-05-15T00:00:00Z