Pre-mRNA splicing within an assembled yeast spliceosome requires an RNA-dependent ATPase and ATP hydrolysis
about
The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicasesCloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43Elevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation.The splicing factor PRP2, a putative RNA helicase, interacts directly with pre-mRNASpliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicingThe DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.A novel splicing factor, Yju2, is associated with NTC and acts after Prp2 in promoting the first catalytic reaction of pre-mRNA splicing.Prp43 is an essential RNA-dependent ATPase required for release of lariat-intron from the spliceosome.Progression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociationPrp22, a DExH-box RNA helicase, plays two distinct roles in yeast pre-mRNA splicingInteractions between highly conserved U2 small nuclear RNA structures and Prp5p, Prp9p, Prp11p, and Prp21p proteins are required to ensure integrity of the U2 small nuclear ribonucleoprotein in Saccharomyces cerevisiaeThe DEAH-box protein PRP22 is an ATPase that mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes.Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae.The final stages of spliceosome maturation require Spp2p that can interact with the DEAH box protein Prp2p and promote step 1 of splicing.Contribution of DEAH-box protein DHX16 in human pre-mRNA splicingSF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeastNuclear retention of unspliced pre-mRNAs by mutant DHX16/hPRP2, a spliceosomal DEAH-box protein.The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex.Dominant negative mutants of the yeast splicing factor Prp2 map to a putative cleft region in the helicase domain of DExD/H-box proteins.Definition of a spliceosome interaction domain in yeast Prp2 ATPase.Mutational analysis of the yeast DEAH-box splicing factor Prp16.A mutation in a methionine tRNA gene suppresses the prp2-1 Ts mutation and causes a pre-mRNA splicing defect in Saccharomyces cerevisiae.GPKOW is essential for pre-mRNA splicing in vitro and suppresses splicing defect caused by dominant-negative DHX16 mutation in vivo.Functional roles of protein splicing factors.The interaction of Prp2 with a defined region of the intron is required for the first splicing reaction.Prp43: An RNA helicase-like factor involved in spliceosome disassembly.A connection between pre-mRNA splicing and the cell cycle in fission yeast: cdc28+ is allelic with prp8+ and encodes an RNA-dependent ATPase/helicaseProbing interactions between the U2 small nuclear ribonucleoprotein and the DEAD-box protein, Prp5.Extensive interactions of PRP8 protein with the 5' and 3' splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA.Genetic studies of the PRP17 gene of Saccharomyces cerevisiae: a domain essential for function maps to a nonconserved region of the protein.Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions.Splicing of a circular yeast pre-mRNA in vitro.Remodeling of U2-U6 snRNA helix I during pre-mRNA splicing by Prp16 and the NineTeen Complex protein Cwc2Mutations in PRP43 that uncouple RNA-dependent NTPase activity and pre-mRNA splicing function.Motifs IV and V in the DEAH box splicing factor Prp22 are important for RNA unwinding, and helicase-defective Prp22 mutants are suppressed by Prp8.
P2860
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P2860
Pre-mRNA splicing within an assembled yeast spliceosome requires an RNA-dependent ATPase and ATP hydrolysis
description
1993 nî lūn-bûn
@nan
1993 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Pre-mRNA splicing within an as ...... dent ATPase and ATP hydrolysis
@ast
Pre-mRNA splicing within an as ...... dent ATPase and ATP hydrolysis
@en
Pre-mRNA splicing within an as ...... ent ATPase and ATP hydrolysis.
@nl
type
label
Pre-mRNA splicing within an as ...... dent ATPase and ATP hydrolysis
@ast
Pre-mRNA splicing within an as ...... dent ATPase and ATP hydrolysis
@en
Pre-mRNA splicing within an as ...... ent ATPase and ATP hydrolysis.
@nl
prefLabel
Pre-mRNA splicing within an as ...... dent ATPase and ATP hydrolysis
@ast
Pre-mRNA splicing within an as ...... dent ATPase and ATP hydrolysis
@en
Pre-mRNA splicing within an as ...... ent ATPase and ATP hydrolysis.
@nl
P2860
P356
P1476
Pre-mRNA splicing within an as ...... dent ATPase and ATP hydrolysis
@en
P2860
P304
P356
10.1073/PNAS.90.3.888
P407
P577
1993-02-01T00:00:00Z