Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification
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Recent Advances in Development and Application of Physiologically-Based Pharmacokinetic (PBPK) Models: a Transition from Academic Curiosity to Regulatory AcceptanceA survey of renal impairment pharmacokinetic studies for new oncology drug approvals in the USA from 2010 to early 2015: a focus on development strategies and future directionsWhat Can Be Learned from Recent New Drug Applications? A Systematic Review of Drug Interaction Data for Drugs Approved by the US FDA in 2015.Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on IrinotecApplication of Physiologically Based Absorption Modeling to Characterize the Pharmacokinetic Profiles of Oral Extended Release Methylphenidate Products in AdultsGood Practices in Model-Informed Drug Discovery and Development: Practice, Application, and DocumentationTowards a Best Practice Approach in PBPK Modeling: Case Example of Developing a Unified Efavirenz Model Accounting for Induction of CYPs 3A4 and 2B6Quantitative Systems Pharmacology: A Framework for Context.An evidence-based recommendation to increase the dosing frequency of buprenorphine during pregnancy.Multiscale Modeling in the Clinic: Drug Design and DevelopmentPhysiologically Based Pharmacokinetic Modeling in Pediatric Oncology Drug Development.Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling.Mathematical modeling and simulation in animal health - Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment.Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate.Causes and Consequences of Variability in Drug Transporter Activity in Pediatric Drug Therapy.Progress in Prediction and Interpretation of Clinically Relevant Metabolic Drug-Drug Interactions: a Minireview Illustrating Recent Developments and Current Opportunities.Physiologically Based Pharmacokinetic (PBPK) Modeling of Pitavastatin and Atorvastatin to Predict Drug-Drug Interactions (DDIs).Assessment of DCE-MRI parameters for brain tumors through implementation of physiologically-based pharmacokinetic model approaches for Gd-DOTA.The application of physiologically-based pharmacokinetic modelling to assess the impact of antiretroviral-mediated drug-drug interactions on piperaquine antimalarial therapy during pregnancy.Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.Humans Vary, So Cardiac Models Should Account for That Too!Ribociclib Bioavailability Is Not Affected by Gastric pH Changes or Food Intake: In Silico and Clinical Evaluations.Reduced order modeling and analysis of the human complement system.Physiologically Based Pharmacokinetic Modeling to Evaluate the Systemic Exposure of Gefitinib in CYP2D6 Ultrarapid Metabolizers and Extensive Metabolizers.Prediction of drug-drug interaction potential using physiologically based pharmacokinetic modeling.Development of Guanfacine Extended-Release Dosing Strategies in Children and Adolescents with ADHD Using a Physiologically Based Pharmacokinetic Model to Predict Drug-Drug Interactions with Moderate CYP3A4 Inhibitors or Inducers.The feasibility of physiologically based pharmacokinetic modeling in forensic medicine illustrated by the example of morphine.Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software.Physiologically Based Pharmacokinetic Prediction of Linezolid and Emtricitabine in Neonates and Infants.A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions.Development and validation of a physiology-based model for the prediction of pharmacokinetics/toxicokinetics in rabbits.Physiologically-based pharmacokinetic model of vaginally administered dapivirine ring and film formulationsBridging the Data Gap From Toxicity Testing to Chemical Safety Assessment Through Computational Modeling
P2860
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P2860
Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification
description
2015 nî lūn-bûn
@nan
2015 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Physiologically Based Pharmaco ...... ations, and Model Verification
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Physiologically Based Pharmaco ...... ations, and Model Verification
@en
Physiologically Based Pharmaco ...... ations, and Model Verification
@nl
type
label
Physiologically Based Pharmaco ...... ations, and Model Verification
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Physiologically Based Pharmaco ...... ations, and Model Verification
@en
Physiologically Based Pharmaco ...... ations, and Model Verification
@nl
prefLabel
Physiologically Based Pharmaco ...... ations, and Model Verification
@ast
Physiologically Based Pharmaco ...... ations, and Model Verification
@en
Physiologically Based Pharmaco ...... ations, and Model Verification
@nl
P2093
P2860
P3181
P356
P1476
Physiologically Based Pharmaco ...... ations, and Model Verification
@en
P2093
I. Ragueneau-Majlessi
J. E. Sager
N. Isoherranen
P2860
P304
P3181
P356
10.1124/DMD.115.065920
P407
P577
2015-11-01T00:00:00Z