Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
about
Genetic determinants and potential therapeutic targets for pancreatic adenocarcinomaThe Role of PARP Inhibitors in the Treatment of Gynecologic MalignanciesPoly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancerDNA-repair pathway inhibitors for the treatment of ovarian cancerPersonalized medicine: hope or hype?Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylationFIGNL1-containing protein complex is required for efficient homologous recombination repairSynaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2Inhibition of homologous recombination by the PCNA-interacting protein PARIHuman SIRT6 promotes DNA end resection through CtIP deacetylationMechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancerDNA end resection by CtIP and exonuclease 1 prevents genomic instabilityMetnase promotes restart and repair of stalled and collapsed replication forksHomologous-recombination-deficient tumours are dependent on Polθ-mediated repairBreast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forksRad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaksFBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistanceTargeting abnormal DNA repair in therapy-resistant breast cancersThe DNA-damage response in human biology and diseaseDetection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencingTargeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugsFailure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitroUnderstanding and treating triple-negative breast cancerSusceptibility pathways in Fanconi's anemia and breast cancerBRCAness: finding the Achilles heel in ovarian cancerSuppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapyMutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencingPARP1 suppresses homologous recombination events in mice in vivoMicroRNA-182-5p targets a network of genes involved in DNA repairHow the fanconi anemia pathway guards the genomeHigh sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugsRational design of human DNA ligase inhibitors that target cellular DNA replication and repairIdentifying druggable disease-modifying gene productsFragile histidine triad protein, WW domain-containing oxidoreductase protein Wwox, and activator protein 2gamma expression levels correlate with basal phenotype in breast cancerHDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombinationBRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolutionPoly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by P53XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damageInhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair
P2860
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P2860
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
description
2005 nî lūn-bûn
@nan
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Specific killing of BRCA2-defi ...... of poly(ADP-ribose) polymerase
@ast
Specific killing of BRCA2-defi ...... of poly(ADP-ribose) polymerase
@en
Specific killing of BRCA2-defi ...... of poly(ADP-ribose) polymerase
@nl
type
label
Specific killing of BRCA2-defi ...... of poly(ADP-ribose) polymerase
@ast
Specific killing of BRCA2-defi ...... of poly(ADP-ribose) polymerase
@en
Specific killing of BRCA2-defi ...... of poly(ADP-ribose) polymerase
@nl
prefLabel
Specific killing of BRCA2-defi ...... of poly(ADP-ribose) polymerase
@ast
Specific killing of BRCA2-defi ...... of poly(ADP-ribose) polymerase
@en
Specific killing of BRCA2-defi ...... of poly(ADP-ribose) polymerase
@nl
P2093
P2860
P3181
P356
P1433
P1476
Specific killing of BRCA2-defi ...... of poly(ADP-ribose) polymerase
@en
P2093
Dan Flower
Elena Lopez
Helen E Bryant
Huw D Thomas
Kayan M Parker
Mark Meuth
Niklas Schultz
Suzanne Kyle
P2507
P2860
P2888
P304
P3181
P356
10.1038/NATURE03443
P407
P577
2005-04-01T00:00:00Z
P5875
P6179
1036499081