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Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease modelsTransthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?Adult bone marrow: which stem cells for cellular therapy protocols in neurodegenerative disorders?The amyloid precursor protein (APP) does not have a ferroxidase site in its E2 domainNeurotrophic factors in Alzheimer’s disease: role of axonal transportCLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXVGrowth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor proteinA presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.Gamma-secretase activating protein is a therapeutic target for Alzheimer's diseaseExtracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease.XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanismsGene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brainSORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processesA polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease riskCD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide productionImplications of the serine protease HtrA1 in amyloid precursor protein processingSyntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide productionThe gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signalingAssociation of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.The potential role of amyloid beta in the pathogenesis of age-related macular degeneration.The amyloid-beta precursor protein: integrating structure with biological functionCholesterol, lipid rafts, and diseaseNicalin and its binding partner Nomo are novel Nodal signaling antagonistsDissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's diseaseImmunization with the SDPM1 peptide lowers amyloid plaque burden and improves cognitive function in the APPswePSEN1(A246E) transgenic mouse model of Alzheimer's disease.Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivoTherapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorderAmyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patientsMolecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.De novo proteins from designed combinatorial librariesLipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's diseaseInteraction of reelin with amyloid precursor protein promotes neurite outgrowthSignaling effect of amyloid-beta(42) on the processing of AbetaPPHippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's diseaseAmyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid raftsValsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer diseaseNSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivoInhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein.Innate immunity and inflammation in ageing: a key for understanding age-related diseasesPrediction of "hot spots" of aggregation in disease-linked polypeptides
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Alzheimer's disease: genes, proteins, and therapy
@ast
Alzheimer's disease: genes, proteins, and therapy
@en
Alzheimer's disease: genes, proteins, and therapy
@nl
type
label
Alzheimer's disease: genes, proteins, and therapy
@ast
Alzheimer's disease: genes, proteins, and therapy
@en
Alzheimer's disease: genes, proteins, and therapy
@nl
prefLabel
Alzheimer's disease: genes, proteins, and therapy
@ast
Alzheimer's disease: genes, proteins, and therapy
@en
Alzheimer's disease: genes, proteins, and therapy
@nl
P3181
P1476
Alzheimer's disease: genes, proteins, and therapy
@en
P2093
D J Selkoe
P304
P3181
P356
10.1152/PHYSREV.2001.81.2.741
P407
P577
2001-04-01T00:00:00Z