Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation
about
Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2.The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding theHomophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2Membrane type 1 matrix metalloproteinase and gelatinase A synergistically degrade type 1 collagen in a cell model.TNF alpha-mediated disruption of spermatogenesis in response to Sertoli cell injury in rodents is partially regulated by MMP2Regulation and involvement of matrix metalloproteinases in vascular diseasesInterleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expressionTIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domains.Discovery of chemokine substrates for matrix metalloproteinases by exosite scanning: a new tool for degradomics.Proteolysis during tumor cell extravasation in vitro: metalloproteinase involvement across tumor cell types.Matrix metalloproteinases promote inflammation and fibrosis in asbestos-induced lung injury in miceMatrix metalloproteinases in cancer: comparison of known and novel aspects of their inhibition as a therapeutic approach.Inhibition of beta-ionone on SGC-7901 cell proliferation and upregulation of metalloproteinases-1 and -2 expression.The miR-130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN.Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis.Tissue inhibitor of metalloproteinases-4. The road less traveled.Peptide from the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) inhibits membrane activation of matrix metalloproteinase-2 (MMP-2).Intricate Functions of Matrix Metalloproteinases in Physiological and Pathological Conditions.Leptin-promoted human extravillous trophoblast invasion is MMP14 dependent and requires the cross talk between Notch1 and PI3K/Akt signaling.Regulation of MMP-2 expression and activity by β-1,3-N-acetylglucosaminyltransferase-8 in AGS gastric cancer cells.Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism.Dynamics of internalization and recycling of the prometastatic membrane type 4 matrix metalloproteinase (MT4-MMP) in breast cancer cells.The CXCR4/SDF1 axis improves muscle regeneration through MMP-10 activityInduction of membrane-type-1 matrix metalloproteinase by epidermal growth factor-mediated signaling in gliomas.Selective involvement of TIMP-2 in the second activational cleavage of pro-MMP-2: refinement of the pro-MMP-2 activation mechanism.Oligomerization through hemopexin and cytoplasmic domains regulates the activity and turnover of membrane-type 1 matrix metalloproteinase.Transient collagen triple helix binding to a key metalloproteinase in invasion and development.Role of N-glycosylation in activation of proMMP-9. A molecular dynamics simulations study.Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage.Association of SNPs in the TIMP-2 gene and large artery atherosclerotic stroke in southern Chinese Han population.Biochemical and Biological Attributes of Matrix Metalloproteinases.The proteolytic activity of MT4-MMP is required for its pro-angiogenic and pro-metastatic promoting effects.
P2860
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P2860
Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Domain interactions in the gel ...... dulate gelatinase A activation
@ast
Domain interactions in the gel ...... dulate gelatinase A activation
@en
Domain interactions in the gel ...... dulate gelatinase A activation
@nl
type
label
Domain interactions in the gel ...... dulate gelatinase A activation
@ast
Domain interactions in the gel ...... dulate gelatinase A activation
@en
Domain interactions in the gel ...... dulate gelatinase A activation
@nl
prefLabel
Domain interactions in the gel ...... dulate gelatinase A activation
@ast
Domain interactions in the gel ...... dulate gelatinase A activation
@en
Domain interactions in the gel ...... dulate gelatinase A activation
@nl
P2093
P2860
P356
P1476
Domain interactions in the gel ...... dulate gelatinase A activation
@en
P2093
C M Overall
C Morrison
C R Roberts
G A McQuibban
U M Wallon
P2860
P304
P356
10.1074/JBC.M005932200
P407
P577
2000-12-15T00:00:00Z