c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia - Wikidata - thesis-toulmin - TriplyDB

c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

http://www.wikidata.org/entity/Q28141146

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The molecular mechanisms that control thrombopoiesis Megakaryocyte biology and related disorders Clinical indications for thrombopoietin and thrombopoietin-receptor agonists Exome sequencing identifies MPL as a causative gene in familial aplastic anemia The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells.Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2 MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling The genomics of inherited bone marrow failure: from mechanism to the clinic.Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis.Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity Autoantibody to c-Mpl (thrombopoietin receptor) in systemic lupus erythematosus: relationship to thrombocytopenia with megakaryocytic hypoplasia.Thrombopoietin is essential for the maintenance of normal hematopoiesis in humans: development of aplastic anemia in patients with congenital amegakaryocytic thrombocytopenia.Allogeneic stem cell transplantation for patients with congenital amegakaryocytic thrombocytopenia (CAT).A neonate with severe thrombocytopenia and radio-ulnar synostosis.Thrombopoietin regulates differentiation of rhesus monkey embryonic stem cells to hematopoietic cells.Qualitative disorders of platelets and megakaryocytes.The molecular basis of congenital thrombocytopenias: insights into megakaryopoiesis.Congenital amegakaryocytic thrombocytopenia: a retrospective clinical analysis of 20 patients.Current diagnosis of inherited bone marrow failure syndromes.Characterization of a patient with atypical amegakaryocytic thrombocytopenia.Historical review: megakaryopoiesis and thrombopoiesis JAK and MPL mutations in myeloid malignancies.Functional analysis of single amino-acid mutations in the thrombopoietin-receptor Mpl underlying congenital amegakaryocytic thrombocytopenia.An ENU-induced recessive mutation in Mpl leads to thrombocytopenia with overdominance Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia Compound heterozygous c-Mpl mutations in a child with congenital amegakaryocytic thrombocytopenia: functional characterization and a review of the literature Congenital amegakaryocytic thrombocytopenia and thrombocytopenia with absent radii.Gene therapy of MPL deficiency: challenging balance between leukemia and pancytopenia.Thrombopoietin and platelet production in chronic immune thrombocytopenia.Inherited platelet disorders: thrombocytopenias and thrombocytopathies.F104S c-Mpl responds to a transmembrane domain-binding thrombopoietin receptor agonist: proof of concept that selected receptor mutations in congenital amegakaryocytic thrombocytopenia can be stimulated with alternative thrombopoietic agents.Megakaryopoiesis Current status of thrombopoietic agents.Congenital amegakaryocytic thrombocytopenia: a brief review of the literature CAMT in a female with developmental delay, facial malformations and central nervous system anomalies.Platelet disorders in children: A diagnostic approach.Congenital amegakaryocytic thrombocytopenia.Thrombopoietin and hematopoietic stem cells.Inherited platelet disorders: a clinical approach to diagnosis and management.Nonclinical safety assessment of a synthetic peptide thrombopoietin agonist: effects on platelets, bone homeostasis, and immunogenicity and the implications for clinical safety monitoring of adverse bone effects.

P2860

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P2860

c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

http://www.wikidata.org/entity/Q28141146

description

2001 nî lūn-bûn

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2001 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2001 թվականի հունվարին հրատարակված գիտական հոդված

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c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

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c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

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c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

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c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

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c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

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c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

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c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

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c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

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c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

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congenital amegakaryocytic thrombocytopenia

thrombocytopenia