Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency - Wikidata - thesis-toulmin - TriplyDB

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency

http://www.wikidata.org/entity/Q28144652

about

FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway Rho GTPases in hematopoiesis and hemopathies DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis The molecular pathology of primary immunodeficiencies Genetic disorders coupled to ROS deficiency Congenital defects in neutrophil dynamics Actin cytoskeletal defects in immunodeficiency Leukocyte migration from a fish eye's view The RHO-1 RhoGTPase modulates fertility and multiple behaviors in adult C. elegans Flow Cytometry, a Versatile Tool for Diagnosis and Monitoring of Primary Immunodeficiencies NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2 A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox.The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton Activation of the A(3) adenosine receptor inhibits fMLP-induced Rac activation in mouse bone marrow neutrophils.Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis.Acute progression of BCR-FGFR1 induced murine B-lympho/myeloproliferative disorder suggests involvement of lineages at the pro-B cell stage.Purinergic regulation of neutrophil chemotaxis.Rac2-deficiency leads to exacerbated and protracted colitis in response to Citrobacter rodentium infection Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice.Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models.Proinflammatory responses induced by CD40 in retinal endothelial and Müller cells are inhibited by blocking CD40-Traf2,3 or CD40-Traf6 signaling.Agonist activation of f-actin-mediated eosinophil shape change and mediator release is dependent on Rac2.Role of p47phox in antigen-presenting cell-mediated regulation of humoral immunity in mice.Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue.RAC2 loss-of-function mutation in 2 siblings with characteristics of common variable immunodeficiency.Mice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopietic function.Vav proteins control MyD88-dependent oxidative burst.The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems.CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism.The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)-like disease.Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton.Rac signaling in breast cancer: a tale of GEFs and GAPs.Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization.Live cell evaluation of granzyme delivery and death receptor signaling in tumor cells targeted by human natural killer cells Hem-1: putting the "WAVE" into actin polymerization during an immune response.Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice Neutrophils in host defense: new insights from zebrafish.

P2860

Q24301340-F91DA86C-331C-48EC-83C2-478434A9F9CD Q24652636-EA91CBAD-39D2-41D1-887A-0CFB48784812 Q24683000-A1AC31AE-6140-4615-A3D9-2A1B22C0E8C9 Q24685932-0411C7C9-0C11-4165-8924-F9577CAC9F32 Q26799545-31F37F0B-8D3C-495E-874A-258E6EC4F88A Q26996029-AB40D36B-9B35-4E7B-86D8-92934F8EDA70 Q27021852-24A80817-006A-4720-9D78-8EDC1E6FAC60 Q27025000-46A67B51-E4F0-4112-A0D6-ACEBFC1D1601 Q27350466-BCEEA931-65FA-42D8-9408-08CE4755F5F7 Q28076919-6114604C-E6EB-424B-8D2B-C9F4C155AF77 Q28247419-C5D1C97C-6F29-4A00-B17C-ECAD9D6E52C1 Q28506215-B2D82AD0-B6D4-412B-8B3B-AC0952CE8892 Q28593723-F677A5E2-838A-46AD-BC83-EDAAECF2E3AE Q30478913-7198CAC3-6D60-42FA-ACE2-1478CB4950C2 Q30538230-32D1C2AA-28B4-4E02-B3F1-54F3E79ACB49 Q30555996-EC567901-3466-4800-861A-47F03AD27F80 Q33759296-5ED3FCAE-05F9-44E2-8EE0-84CC99B02B5C Q34236833-3E6AB812-4970-4C5C-AD9E-43637BF3A7D4 Q34305360-BD5BA521-20A2-49BC-8FE0-BAC32A406095 Q34425713-E04AB8FA-99D5-4CC9-9809-C59907C34291 Q34684714-CEEB2520-A2A0-47F5-868D-9EB5D67A9CF1 Q34724992-25448890-7C91-4595-878D-63DD3238356B Q34777511-2E8FBDB0-A738-46B5-B7E3-3674221C4853 Q34795130-F36C00F6-162E-43D6-8453-2E5BD0A0F5CF Q35016132-04708D9B-2792-4B09-A613-B1A625677073 Q35072741-0D872D91-AD34-4F33-B742-B035FBBBF8AA Q35421334-6B7DF0DD-9492-4FF4-9022-46C5E25AB335 Q35589474-6536A67A-4287-4A31-AEE7-8357CD0275C3 Q35633071-B4971C2D-E4C0-460F-B71C-2DEB49FA7C9D Q35751091-0BF6BF04-F3B9-4F2E-B6CD-947EA6198EB4 Q35828194-A4D5E43C-D0DE-494B-AAED-B4A7DDF58548 Q35847956-7002D9B8-D4EA-4FD5-AE37-B3403BEDEA1B Q35848279-02E0C457-B15C-4317-9B07-AFA3FC8BB1DD Q35848885-9ABBBC6D-2B18-417B-A0A0-9184A50CD0A1 Q35854151-BA044E04-EDCF-4898-B57A-763FEE59EAAD Q35888155-9FD5B727-7FC8-4CA9-908B-FC15174EECDE Q35976605-37E5626C-4892-46FC-AD9C-F0C08D678B52 Q35998040-5440D5A0-030A-41BD-A537-4C9F0EFD6EDD Q36025303-A59A9164-EB13-45BD-8591-9D85054B423C Q36057930-22FA7744-29E1-46BA-9313-DED95C1A1C46

P2860

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency

http://www.wikidata.org/entity/Q28144652

description

2000 nî lūn-bûn

@nan

2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

Dominant negative mutation of ...... man phagocyte immunodeficiency

@ast

Dominant negative mutation of ...... man phagocyte immunodeficiency

@en

Dominant negative mutation of ...... man phagocyte immunodeficiency

@nl

type

label

Dominant negative mutation of ...... man phagocyte immunodeficiency

@ast

Dominant negative mutation of ...... man phagocyte immunodeficiency

@en

Dominant negative mutation of ...... man phagocyte immunodeficiency

@nl

prefLabel

Dominant negative mutation of ...... man phagocyte immunodeficiency

@ast

Dominant negative mutation of ...... man phagocyte immunodeficiency

@en

Dominant negative mutation of ...... man phagocyte immunodeficiency

@nl

P1433

Q28144652-B5DEC750-F5EC-4E79-8A66-10F69ACADC0E

P1476

Q28144652-5791F280-7C2E-45AE-9B10-8284E89DFC06

P2093

Q28144652-090FC503-5295-45FD-81DE-41596A9837B8

Q28144652-34BE1FEB-B497-42CE-96B7-056DD50D323B

Q28144652-3E4E4720-1D31-41F1-B108-BD537CE0DC18

Q28144652-4E1BBBBB-00ED-4689-B716-B6604D3DC830

Q28144652-50C662CF-07F9-4FB5-82C5-212D6C594FE7

Q28144652-54DE6253-5BE3-4E12-BA58-A45262B20505

Q28144652-55D465EF-3109-4F19-8C0E-1F1CAB395B1C

Q28144652-5EAD9C98-798D-4162-9F1E-0BA3658C6137

Q28144652-61AD5D47-BD9A-4B7B-909B-F984C5154C96

Q28144652-77849A5B-34BB-421F-83CD-57D0ADBDEF40

P304

Q28144652-4212D1D7-335E-4903-B750-3356DF52EC48

P31

Q28144652-E0EAA2D0-3372-4ADC-AE60-CA0133575E8A

P407

Q28144652-E2E846B2-4CB8-45CE-8055-57F08C159B8E

P433

Q28144652-6378B21F-E98C-43F5-B7F2-CDD788580B91

P478

Q28144652-00AEB7C6-9E31-4231-8658-DEFEBCD51C95

P577

Q28144652-33C04019-D10E-40BE-9464-F2C4BBAA9EFA

P698

Q28144652-921F46D7-266B-4CCD-A90B-1C841362EB30

P1433

P1476

Dominant negative mutation of ...... man phagocyte immunodeficiency

@en

P2093

B Jia

http://www.w3.org/2001/XMLSchema#string

B Petryniak

http://www.w3.org/2001/XMLSchema#string

C Harris

http://www.w3.org/2001/XMLSchema#string

C Kim

http://www.w3.org/2001/XMLSchema#string

C W Derrow

http://www.w3.org/2001/XMLSchema#string

D A Williams

http://www.w3.org/2001/XMLSchema#string

D R Ambruso

http://www.w3.org/2001/XMLSchema#string

F Yang

http://www.w3.org/2001/XMLSchema#string

J B Lowe

http://www.w3.org/2001/XMLSchema#string

J E Levine

http://www.w3.org/2001/XMLSchema#string

P304

1646-54

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

96

http://www.w3.org/2001/XMLSchema#string

P577

2000-09-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

10961859

http://www.w3.org/2001/XMLSchema#string