Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation
about
p56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transductionT cell regulation of p62(dok) (Dok1) association with Crk-LRap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowthDok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak.A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and functionNovel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiationDok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganizationCoupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responsesp62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl)Nck adapter proteins: functional versatility in T cellsNck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress.Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling.Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction.Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays.The downstream of tyrosine kinase 7 is reduced in lung cancer and is associated with poor survival of patients with lung cancerDOK4 and DOK5: new Dok-related genes expressed in human T cells.Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.Identification of DOK genes as lung tumor suppressors.DOK2 inhibits EGFR-mutated lung adenocarcinoma.Adaptors as central mediators of signal transduction in immune cells.Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformationSH2 and PTB domains in tyrosine kinase signaling.Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling.The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase LynEnhanced enteroviral infectivity via viral protease-mediated cleavage of Grb2-associated binder 1.Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sitesPhosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation.ErbB receptors and epithelial-cadherin-catenin complex in human carcinomas.Docking proteins.Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.Inhibition of the motility and growth of B16F10 mouse melanoma cells by dominant negative mutants of Dok-1.Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer.Dok-1 tyrosine residues at 336 and 340 are essential for the negative regulation of Ras-Erk signalling, but dispensable for rasGAP-binding.Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells.Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis.Mutational and expressional analysis of a haploinsufficient tumor suppressor gene DOK2 in gastric and colorectal cancers.DOK2 as a marker of poor prognosis of patients with gastric adenocarcinoma after curative resection.
P2860
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P2860
Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation
description
1999 nî lūn-bûn
@nan
1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Recruitment of Dok-R to the EG ...... n of Erk MAP kinase activation
@ast
Recruitment of Dok-R to the EG ...... n of Erk MAP kinase activation
@en
Recruitment of Dok-R to the EG ...... n of Erk MAP kinase activation
@nl
type
label
Recruitment of Dok-R to the EG ...... n of Erk MAP kinase activation
@ast
Recruitment of Dok-R to the EG ...... n of Erk MAP kinase activation
@en
Recruitment of Dok-R to the EG ...... n of Erk MAP kinase activation
@nl
prefLabel
Recruitment of Dok-R to the EG ...... n of Erk MAP kinase activation
@ast
Recruitment of Dok-R to the EG ...... n of Erk MAP kinase activation
@en
Recruitment of Dok-R to the EG ...... n of Erk MAP kinase activation
@nl
P1433
P1476
Recruitment of Dok-R to the EG ...... n of Erk MAP kinase activation
@en
P2093
P304
P356
10.1016/S0960-9822(99)80458-8
P407
P577
1999-09-23T00:00:00Z