A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels
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The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression levelIto channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2I SA channel complexes include four subunits each of DPP6 and Kv4.2Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunitsExpression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamerA VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channelsSpecific effects of KChIP3/calsenilin/DREAM, but not KChIPs 1, 2 and 4, on calcium signalling and regulated secretion in PC12 cellsNeuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signallingTransmural expression of transient outward potassium current subunits in normal and failing canine and human heartsTraffic of Kv4 K+ channels mediated by KChIP1 is via a novel post-ER vesicular pathwayStructural Insights into KChIP4a Modulation of Kv4.3 InactivationInteractions of the proteins of neuronal ceroid lipofuscinosis: clues to functionProteomic analyses of native brain K(V)4.2 channel complexesC-terminal domain of Kv4.2 and associated KChIP2 interactions regulate functional expression and gating of Kv4.2SAP97 directs the localization of Kv4.2 to spines in hippocampal neurons: regulation by CaMKIIKv4 potassium channel subunits control action potential repolarization and frequency-dependent broadening in rat hippocampal CA1 pyramidal neuronesLocalization of Kv4.2 and KChIP2 in lipid rafts and modulation of outward K+ currents by membrane cholesterol content in rat left ventricular myocytesThe homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradientAugmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilizationInterdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neuronsAnalysis and functional implications of phosphorylation of neuronal voltage-gated potassium channels.Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy.Localization and targeting of voltage-dependent ion channels in mammalian central neurons.Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant mannerA secretory-type protein, containing a pentraxin domain, interacts with an A-type K+ channel.Spatial distributions of Kv4 channels and KChip2 isoforms in the murine heart based on laser capture microdissection.Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulationThe DREAM protein is associated with thyroid enlargement and nodular development.KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neurons.Neuronal calcium sensor-1 (Ncs1p) is up-regulated by calcineurin to promote Ca2+ tolerance in fission yeast.Multi-walled carbon nanotubes impair Kv4.2/4.3 channel activities, delay membrane repolarization and induce bradyarrhythmias in the rat.Inhibition of A-type potassium current by the peptide toxin SNX-482Functional rescue of Kv4.3 channel tetramerization mutants by KChIP4a.The A-current modulates learning via NMDA receptors containing the NR2B subunitThe membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner.Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.Co-assembly of Kv4 {alpha} subunits with K+ channel-interacting protein 2 stabilizes protein expression and promotes surface retention of channel complexesNeuronal voltage-gated K+ (Kv) channels function in macromolecular complexes.
P2860
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P2860
A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
A fundamental role for KChIPs ...... ng of Kv4.2 potassium channels
@ast
A fundamental role for KChIPs ...... ng of Kv4.2 potassium channels
@en
A fundamental role for KChIPs ...... ng of Kv4.2 potassium channels
@nl
type
label
A fundamental role for KChIPs ...... ng of Kv4.2 potassium channels
@ast
A fundamental role for KChIPs ...... ng of Kv4.2 potassium channels
@en
A fundamental role for KChIPs ...... ng of Kv4.2 potassium channels
@nl
prefLabel
A fundamental role for KChIPs ...... ng of Kv4.2 potassium channels
@ast
A fundamental role for KChIPs ...... ng of Kv4.2 potassium channels
@en
A fundamental role for KChIPs ...... ng of Kv4.2 potassium channels
@nl
P2093
P356
P1476
A fundamental role for KChIPs ...... ng of Kv4.2 potassium channels
@en
P2093
Anne E Anderson
Claire R Campomanes
J David Sweatt
James S Trimmer
Karen I Carroll
Kenneth J Rhodes
Laura A Schrader
Lisa C Doliveira
Riichi Shibata
P304
P356
10.1074/JBC.M306142200
P407
P577
2003-09-19T00:00:00Z