Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation
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Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cellsDefining the functional domain of programmed cell death 10 through its interactions with phosphatidylinositol-3,4,5-trisphosphate.T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis.R-RAS2 overexpression in tumors of the human central nervous system.Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomasH-Ras, R-Ras, and TC21 differentially regulate ureteric bud cell branching morphogenesisDistinct requirements for Ras oncogenesis in human versus mouse cells.The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery.PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development.Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factorsHigh-throughput analysis reveals novel maternal germline RNAs crucial for primordial germ cell preservation and proper migration.Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease.siRNA-mediated downregulation of TC21 sensitizes esophageal cancer cells to cisplatin.Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate.Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins.RRas2, RhoG and T-cell phagocytosis.SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.Oncogenic Ras-mediated downregulation of Gadd153/CHOP is required for Ras-induced cellular transformation.The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.TC21/R-Ras2 upregulation in esophageal tumorigenesis: potential diagnostic implications.
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P2860
Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation
description
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2002
@ast
im März 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 22 March 2002)
@en
vedecký článok (publikovaný 2002/03/22)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/03/22)
@nl
наукова стаття, опублікована в березні 2002
@uk
name
Involvement of phosphatidylino ...... R-Ras2-mediated transformation
@ast
Involvement of phosphatidylino ...... R-Ras2-mediated transformation
@en
Involvement of phosphatidylino ...... R-Ras2-mediated transformation
@nl
type
label
Involvement of phosphatidylino ...... R-Ras2-mediated transformation
@ast
Involvement of phosphatidylino ...... R-Ras2-mediated transformation
@en
Involvement of phosphatidylino ...... R-Ras2-mediated transformation
@nl
prefLabel
Involvement of phosphatidylino ...... R-Ras2-mediated transformation
@ast
Involvement of phosphatidylino ...... R-Ras2-mediated transformation
@en
Involvement of phosphatidylino ...... R-Ras2-mediated transformation
@nl
P2093
P2860
P356
P1476
Involvement of phosphatidylino ...... R-Ras2-mediated transformation
@en
P2093
Anne Vojtek
Channing J Der
Grant G Kelley
Gretchen A Murphy
Kelley Rogers-Graham
Sarah E Reks
Staeci Morita
Suzanne M Graham
P2860
P304
P356
10.1074/JBC.M109059200
P407
P577
2002-03-22T00:00:00Z