Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
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Down syndrome: searching for the genetic culpritsCdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interactionMegakaryocyte biology and related disordersJun blockade of erythropoiesis: role for repression of GATA-1 by HERP2.Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connectionCyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidizationDown syndrome and leukemia: insights into leukemogenesis and translational targetsGenomic landscape of megakaryopoiesis and platelet function defectsMaster regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignanciesGATA family transcriptional factors: emerging suspects in hematologic disordersThe biology of pediatric acute megakaryoblastic leukemiaPrognosis and management of acute myeloid leukemia in patients with Down syndromeMyeloid leukemia in Down syndromeIsoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1The emerging role of GATA transcription factors in development and diseaseTransient Abnormal Myelopoiesis and AML in Down Syndrome: an UpdateThe secret life of a megakaryocyte: emerging roles in bone marrow homeostasis controlMegakaryopoiesis and platelet production: insight into hematopoietic stem cell proliferation and differentiationTranscription factor GATA-1 and Down syndrome leukemogenesisFOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1.Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancyGATA switches as developmental driversMolecular hallmarks of endogenous chromatin complexes containing master regulators of hematopoiesisRbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiationSCL and associated proteins distinguish active from repressive GATA transcription factor complexesETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cellsHematopoiesis: an evolving paradigm for stem cell biologyCross-talk of GATA-1 and P-TEFb in megakaryocyte differentiation.Oncogenic pathways of AML1-ETO in acute myeloid leukemia: multifaceted manipulation of marrow maturation.Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and developmentLoss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineageA mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia.Treatment and prognostic impact of transient leukemia in neonates with Down syndromeHuman phenotypes associated with GATA-1 mutations.The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.Loss of the Gata1 gene IE exon leads to variant transcript expression and the production of a GATA1 protein lacking the N-terminal domainHematological disorders and leukemia in children with Down syndrome.Concomitant a novel ALAS2 mutation and GATA1 mutation in a newborn: a case report and review of the literature.Repercussion of Megakaryocyte-Specific Gata1 Loss on Megakaryopoiesis and the Hematopoietic Precursor Compartment.GATA factor mutations in hematologic disease.
P2860
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P2860
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
@ast
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
@en
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
@nl
type
label
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
@ast
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
@en
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
@nl
prefLabel
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
@ast
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
@en
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
@nl
P2093
P3181
P356
P1433
P1476
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
@en
P2093
John Anastasi
Judith E Karp
Marianne Greene
Michael A McDevitt
Michelle M Le Beau
P2888
P304
P3181
P356
10.1038/NG955
P407
P577
2002-09-01T00:00:00Z