Calcium, thin filaments, and the integrative biology of cardiac contractility
about
Raf-1: a novel cardiac troponin T kinaseCysteine oxidative posttranslational modifications: emerging regulation in the cardiovascular systemIntegration of troponin I phosphorylation with cardiac regulatory networksSmall G proteins in the cardiovascular system: physiological and pathological aspectsRationally engineered Troponin C modulates in vivo cardiac function and performance in health and diseaseCalcium induced regulation of skeletal troponin--computational insights from molecular dynamics simulationsMyosin Binding Protein C Positioned to Play a Key Role in Regulation of Muscle Contraction: Structure and Interactions of Domain C1Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch region of cardiac troponin I and W7: The basis of W7 as an inhibitor of cardiac muscle contractionCardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy PhenotypePhosphorylation, but not alternative splicing or proteolytic degradation, is conserved in human and mouse cardiac troponin TPhosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytesComputer-aided drug discovery approach finds calcium sensitizer of cardiac troponinProtein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardiumThe C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filamentsNew insights into the functional significance of the acidic region of the unique N-terminal extension of cardiac troponin IWhy does troponin I have so many phosphorylation sites? Fact and fancyCardiac thin filament regulationDefining the binding site of levosimendan and its analogues in a regulatory cardiac troponin C-troponin I complexEffects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin CStructural basis for the in situ Ca(2+) sensitization of cardiac troponin C by positive feedback from force-generating myosin cross-bridgesCardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivoThin filament mutations: developing an integrative approach to a complex disorderSimultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicologyDisruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in miceIntegrative structural modelling of the cardiac thin filament: energetics at the interface and conservation patterns reveal a spotlight on period 2 of tropomyosinA novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysisMultiple Reaction Monitoring to Identify Site-Specific Troponin I Phosphorylated Residues in the Failing Human HeartA model of calcium activation of the cardiac thin filamentKinetics of cardiac thin-filament activation probed by fluorescence polarization of rhodamine-labeled troponin C in skinned guinea pig trabeculaeQuantitative comparison of sarcomeric phosphoproteomes of neonatal and adult rat hearts.Troponin regulatory function and dynamics revealed by H/D exchange-mass spectrometry.Biomechanics of cardiac electromechanical coupling and mechanoelectric feedback.Reduced force production during low blood flow to the heart correlates with altered troponin I phosphorylationCardiac myosin is a substrate for zipper-interacting protein kinase (ZIPK)Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryoCardiac troponin T, a sarcomeric AKAP, tethers protein kinase A at the myofilaments.Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems.Phosphorylation of cardiac troponin I at protein kinase C site threonine 144 depresses cooperative activation of thin filaments.Calcium sensitivity, force frequency relationship and cardiac troponin I: critical role of PKA and PKC phosphorylation sitesMyofilament length dependent activation
P2860
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P2860
Calcium, thin filaments, and the integrative biology of cardiac contractility
description
2005 nî lūn-bûn
@nan
2005 թուականին հրատարակուած գիտական յօդուած
@hyw
2005 թվականին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Calcium, thin filaments, and the integrative biology of cardiac contractility
@ast
Calcium, thin filaments, and the integrative biology of cardiac contractility
@en
Calcium, thin filaments, and the integrative biology of cardiac contractility
@nl
type
label
Calcium, thin filaments, and the integrative biology of cardiac contractility
@ast
Calcium, thin filaments, and the integrative biology of cardiac contractility
@en
Calcium, thin filaments, and the integrative biology of cardiac contractility
@nl
prefLabel
Calcium, thin filaments, and the integrative biology of cardiac contractility
@ast
Calcium, thin filaments, and the integrative biology of cardiac contractility
@en
Calcium, thin filaments, and the integrative biology of cardiac contractility
@nl
P3181
P1476
Calcium, thin filaments, and the integrative biology of cardiac contractility
@en
P2093
R John Solaro
Tomoyoshi Kobayashi
P3181
P356
10.1146/ANNUREV.PHYSIOL.67.040403.114025
P407
P577
2005-01-01T00:00:00Z