LRRK2 in Parkinson's disease: protein domains and functional insights
about
Dopamine release in the basal gangliaRac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1Identification of potential protein interactors of Lrrk2Synaptic vesicle trafficking and Parkinson's diseaseInsight into the mode of action of the LRRK2 Y1699C pathogenic mutantArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathwaysIdentification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycleAdult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S miceThe G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutationLeucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's diseaseParkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localizationMedical management of Parkinson's diseaseLRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular modelEvaluation of Models of Parkinson's DiseaseCurrent understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor designMitochondria-Targeted Protective Compounds in Parkinson's and Alzheimer's DiseasesLRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's DiseaseHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsMitochondrial dysfunction and oxidative stress in Parkinson's diseaseThe role of the LRRK2 gene in ParkinsonismNo dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblastsLRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPaseLRRK2 at the interface of autophagosomes, endosomes and lysosomesGene-environment interactions: key to unraveling the mystery of Parkinson's diseaseIdentification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motifThe IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signalingThe nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in DrosophilaLeucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cellsSignal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticityG2385R and I2020T Mutations Increase LRRK2 GTPase ActivityLRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activityA method for WD40 repeat detection and secondary structure prediction.Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway.The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.
P2860
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P2860
LRRK2 in Parkinson's disease: protein domains and functional insights
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
LRRK2 in Parkinson's disease: protein domains and functional insights
@ast
LRRK2 in Parkinson's disease: protein domains and functional insights
@en
LRRK2 in Parkinson's disease: protein domains and functional insights
@nl
type
label
LRRK2 in Parkinson's disease: protein domains and functional insights
@ast
LRRK2 in Parkinson's disease: protein domains and functional insights
@en
LRRK2 in Parkinson's disease: protein domains and functional insights
@nl
prefLabel
LRRK2 in Parkinson's disease: protein domains and functional insights
@ast
LRRK2 in Parkinson's disease: protein domains and functional insights
@en
LRRK2 in Parkinson's disease: protein domains and functional insights
@nl
P2093
P3181
P1476
LRRK2 in Parkinson's disease: protein domains and functional insights
@en
P2093
Ignacio F Mata
Julie P Taylor
Kathleen A Gallo
William J Wedemeyer
P304
P3181
P356
10.1016/J.TINS.2006.03.006
P407
P577
2006-04-17T00:00:00Z