about
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapyBicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cellsTel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexesRequirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cellsRagulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acidsAkt is negatively regulated by the MULAN E3 ligaseThe crosstalk of mTOR/S6K1 and Hedgehog pathwaysNutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagyDEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survivalReassessment of the role of FKBP38 in the Rheb/mTORC1 pathwayHyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83BThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survivalc-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanismsInteraction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) proteinmTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf114-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase functionOver expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathwayPI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancerGOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancerNaturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanismResveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTORMolecular biology of lung cancer: clinical implicationsmTOR inhibitors in advanced renal cell carcinomaHonokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesisOsmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylationDiscovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancerTargeting mTOR for the treatment of AML. New agents and new directionsThe Lin28/let-7 axis regulates glucose metabolismTargeting the mTOR kinase domain: the second generation of mTOR inhibitorsThe mTOR signalling pathway in human cancerMammalian target of rapamycin (mTOR): conducting the cellular signaling symphonyE3 ligase Nedd4 promotes axon branching by downregulating PTENTargeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapyRictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cellsTti1 and Tel2 are critical factors in mammalian target of rapamycin complex assemblymTOR: from growth signal integration to cancer, diabetes and ageingMolecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Defining the role of mTOR in cancer
@ast
Defining the role of mTOR in cancer
@en
Defining the role of mTOR in cancer
@nl
type
label
Defining the role of mTOR in cancer
@ast
Defining the role of mTOR in cancer
@en
Defining the role of mTOR in cancer
@nl
prefLabel
Defining the role of mTOR in cancer
@ast
Defining the role of mTOR in cancer
@en
Defining the role of mTOR in cancer
@nl
P3181
P1433
P1476
Defining the role of mTOR in cancer
@en
P2093
David A Guertin
P3181
P356
10.1016/J.CCR.2007.05.008
P407
P577
2007-07-01T00:00:00Z