Copper is required for oncogenic BRAF signalling and tumorigenesis
about
Molecular imaging and therapy targeting copper metabolism in hepatocellular carcinomaBeyond BRAF: where next for melanoma therapy?Synthetic fluorescent probes for studying copper in biological systemsNew silver nanoparticles induce apoptosis-like process in E. coli and interfere with mammalian copper metabolismCopper regulates cyclic-AMP-dependent lipolysisKRAS-dependent suppression of MYC enhances the sensitivity of cancer cells to cytotoxic agents.Roles of Copper-Binding Proteins in Breast Cancer.Natural variations of copper and sulfur stable isotopes in blood of hepatocellular carcinoma patients.Reduced HRAS G12V-Driven Tumorigenesis of Cell Lines Expressing KRAS C118S.Communication between the N and C termini is required for copper-stimulated Ser/Thr phosphorylation of Cu(I)-ATPase (ATP7B).Pharmacological activity of metal binding agents that alter copper bioavailability.Copper depletion inhibits CoCl2-induced aggressive phenotype of MCF-7 cells via downregulation of HIF-1 and inhibition of Snail/Twist-mediated epithelial-mesenchymal transition.Recognition- and reactivity-based fluorescent probes for studying transition metal signaling in living systems.Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype.The Features of Copper Metabolism in the Rat Liver during DevelopmentThe copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2).Copper Uptake in Mammary Epithelial Cells Activates Cyclins and Triggers Antioxidant ResponsePhospholipid binding to the FAK catalytic domain impacts function.Cisplatin inhibits MEK1/2.The Emerging Hallmarks of Cancer MetabolismInhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferationDisulfiram anti-cancer efficacy without copper overload is enhanced by extracellular H2O2 generation: antagonism by tetrathiomolybdate.Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy.Methanobactin and the Link between Copper and Bacterial Methane OxidationERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability.Transcriptome analysis of copper homeostasis genes reveals coordinated upregulation of SLC31A1,SCO1, and COX11 in colorectal cancer.Bivalent Copper Ions Promote Fibrillar Aggregation of KCTD1 and Induce CytotoxicityIn vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease.Dextran-Catechin: An anticancer chemically-modified natural compound targeting copper that attenuates neuroblastoma growthGenetic variants in ABCG1 are associated with survival of nonsmall-cell lung cancer patients.Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells.Propranolol induced G0/G1/S phase arrest and apoptosis in melanoma cells via AKT/MAPK pathway.Cuprous oxide nanoparticles inhibit prostate cancer by attenuating the stemness of cancer cells via inhibition of the Wnt signaling pathway.Emerging roles of metal solute carriers in cancer mechanisms and treatment.Biological metals and metal-targeting compounds in major neurodegenerative diseases.Targeting copper in cancer therapy: 'Copper That Cancer'.Downregulation of hepatic multi-drug resistance protein 1 (MDR1) after copper exposure.Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines.Filamin A (FLNA) modulates chemosensitivity to docetaxel in triple-negative breast cancer through the MAPK/ERK pathway.Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.
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P2860
Copper is required for oncogenic BRAF signalling and tumorigenesis
description
2014 nî lūn-bûn
@nan
2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Copper is required for oncogenic BRAF signalling and tumorigenesis
@ast
Copper is required for oncogenic BRAF signalling and tumorigenesis
@en
Copper is required for oncogenic BRAF signalling and tumorigenesis
@nl
type
label
Copper is required for oncogenic BRAF signalling and tumorigenesis
@ast
Copper is required for oncogenic BRAF signalling and tumorigenesis
@en
Copper is required for oncogenic BRAF signalling and tumorigenesis
@nl
prefLabel
Copper is required for oncogenic BRAF signalling and tumorigenesis
@ast
Copper is required for oncogenic BRAF signalling and tumorigenesis
@en
Copper is required for oncogenic BRAF signalling and tumorigenesis
@nl
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Copper is required for oncogenic BRAF signalling and tumorigenesis
@en
P2093
Christopher M Counter
Dennis J Thiele
Donita C Brady
Kunhong Xiao
Matthew S Crowe
Michelle L Turski
Sharon L Campbell
Xiaojie Yao
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P2888
P304
P3181
P356
10.1038/NATURE13180
P407
P577
2014-05-22T00:00:00Z
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P6179
1034192748