Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid - Wikidata - thesis-toulmin - TriplyDB

Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid

Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid

http://www.wikidata.org/entity/Q28241946

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International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands Cytochrome P450 ω-Hydroxylases in Inflammation and Cancer The emerging role of oxylipins in thrombosis and diabetes Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid Identification of resolvin D2 receptor mediating resolution of infections and organ protection 12- and 15-lipoxygenases in adipose tissue inflammation Endothelial 12(S)-HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse mesenteric arteries The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor Emerging targets in lipid-based therapy Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation.Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling.12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes.Historical lessons in translational medicine: cyclooxygenase inhibition and P2Y12 antagonism.12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain Convergence of eicosanoid and integrin biology: 12-lipoxygenase seeks a partner.Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor.Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation.Cholesteryl ester acyl oxidation and remodeling in murine macrophages: formation of oxidized phosphatidylcholine.NF-κB contributes to MMP1 expression in breast cancer spheroids causing paracrine PAR1 activation and disintegrations in the lymph endothelial barrier in vitro.Lipids and immunoinflammatory pathways of beta cell destruction.12-HETER1/GPR31, a high-affinity 12(S)-hydroxyeicosatetraenoic acid receptor, is significantly up-regulated in prostate cancer and plays a critical role in prostate cancer progression.Cancer cell-derived 12(S)-HETE signals via 12-HETE receptor, RHO, ROCK and MLC2 to induce lymph endothelial barrier breaching.ETS-1-mediated transcriptional up-regulation of CD44 is required for sphingosine-1-phosphate receptor subtype 3-stimulated chemotaxis.Intercellular Lipid Mediators and GPCR Drug Discovery Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C ε-mediated zona occludens-1 phosphorylation at threonine 770/772.Tracing the dynamics of gene transcripts after organismal death.Eicosanoids and other lipid mediators and the tumor hypoxic microenvironment.Eicosanoids and their drugs in cardiovascular diseases: focus on atherosclerosis and stroke.Molecular biology of atherosclerosis.The obesity-inflammation-eicosanoid axis in breast cancer.Targeted chiral analysis of bioactive arachidonic Acid metabolites using liquid-chromatography-mass spectrometry.The role of mid-chain hydroxyeicosatetraenoic acids in the pathogenesis of hypertension and cardiac hypertrophy.First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer.The G protein-coupled receptor GPR31 promotes membrane association of KRAS.P450 Eicosanoids and Reactive Oxygen Species Interplay in Brain Injury and Neuroprotection.Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis.

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Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid

http://www.wikidata.org/entity/Q28241946

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2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Identification of the orphan G ...... )-hydroxyeicosatetraenoic acid

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Identification of the orphan G ...... )-hydroxyeicosatetraenoic acid

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Identification of the orphan G ...... )-hydroxyeicosatetraenoic acid

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Identification of the orphan G ...... )-hydroxyeicosatetraenoic acid

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Identification of the orphan G ...... )-hydroxyeicosatetraenoic acid

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Identification of the orphan G ...... )-hydroxyeicosatetraenoic acid

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Identification of the orphan G ...... )-hydroxyeicosatetraenoic acid

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Identification of the orphan G ...... )-hydroxyeicosatetraenoic acid

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Identification of the orphan G ...... )-hydroxyeicosatetraenoic acid

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JBC.M110.216564

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Journal of Biological Chemistry

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Identification of the orphan G ...... )-hydroxyeicosatetraenoic acid

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Andrew Hsu

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Ashok-Kumar Dilly

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Craig Giroux

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Jingjing Liu

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Kenneth V Honn

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Menq-Jer Lee

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Prasanna Ekambaram

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Sangeeta Joshi

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Senlin Zhou

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Stephanie C Tucker

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P2860

Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor

Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors

Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth

The 650-kDa 12(S)-hydroxyeicosatetraenoic acid binding complex: occurrence in human platelets, identification of hsp90 as a constituent, and binding properties of its 50-kDa subunit

Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2

Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells

12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids

Overexpression of platelet-type 12-lipoxygenase promotes tumor cell survival by enhancing alpha(v)beta(3) and alpha(v)beta(5) integrin expression.

Mammalian G proteins and their cell type specific functions.

Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse.

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10.1074/JBC.M110.216564

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39

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286

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Krishna Rao Maddipati

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2011-09-30T00:00:00Z

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21712392

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arachidonic acid binding

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G protein-coupled receptor

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3190773

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