The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation
about
DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stabilityProtein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcriptionGSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with AxinDifferential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobinInhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding proteinSynergistic activation of the Wnt signaling pathway by Dvl and casein kinase IepsilonDisulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modulesActivation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signalingStructural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1)Subcellular distribution of Wnt pathway proteins in normal and neoplastic colonI-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways.AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activationAdenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-β-catenin signallingProtein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signallingAxin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.The Axin1 scaffold protein promotes formation of a degradation complex for c-MycAxin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's diseaseA coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5)Axin localizes to the centrosome and is involved in microtubule nucleationMutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancerSignal transduction by the Wnt family of ligandsDesumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin.Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathwayStructural basis of the Axin-adenomatous polyposis coli interactionWrch-1, a novel member of the Rho gene family that is regulated by Wnt-1WISP-1 is a Wnt-1- and beta-catenin-responsive oncogeneWnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLKMaintaining embryonic stem cell pluripotency with Wnt signalingEnvironmental studies of schizophrenia through the prism of epigeneticsSUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stabilityThe Wnt-dependent signaling pathways as target in oncology drug discoveryWnt signaling: the good and the badCasein kinase iepsilon in the wnt pathway: regulation of beta-catenin functionA natural allele of Nxf1 suppresses retrovirus insertional mutationsThe links between axin and carcinogenesisThe ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signalingHMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cellsDomains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localizationEstablishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of dishevelled that is dependent on cortical rotation
P2860
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P2860
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation
description
1997 nî lūn-bûn
@nan
1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The mouse Fused locus encodes ...... lates embryonic axis formation
@ast
The mouse Fused locus encodes ...... lates embryonic axis formation
@en
The mouse Fused locus encodes ...... lates embryonic axis formation
@nl
type
label
The mouse Fused locus encodes ...... lates embryonic axis formation
@ast
The mouse Fused locus encodes ...... lates embryonic axis formation
@en
The mouse Fused locus encodes ...... lates embryonic axis formation
@nl
prefLabel
The mouse Fused locus encodes ...... lates embryonic axis formation
@ast
The mouse Fused locus encodes ...... lates embryonic axis formation
@en
The mouse Fused locus encodes ...... lates embryonic axis formation
@nl
P2093
P3181
P1433
P1476
The mouse Fused locus encodes ...... lates embryonic axis formation
@en
P2093
B M Gumbiner
F Costantini
S M Tilghman
T J Vasicek
P304
P3181
P356
10.1016/S0092-8674(00)80324-4
P407
P50
P577
1997-07-11T00:00:00Z