Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target - Wikidata - thesis-toulmin - TriplyDB

Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target

Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target

http://www.wikidata.org/entity/Q28271520

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The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models.Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer Losses of chromosome 5q and 14q are associated with favorable clinical outcome of patients with gastric cancer Regulation and function of the human HSP90AA1 gene Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model.Overexpression of heat-shock factor 1 is associated with a poor prognosis in esophageal squamous cell carcinoma Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics.A network-based biomarker approach for molecular investigation and diagnosis of lung cancer.Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells.Akt1 deletion prevents lung tumorigenesis by mutant K-ras.Integrative analyses for omics data: a Bayesian mixture model to assess the concordance of ChIP-chip and ChIP-seq measurements.High expression of heat shock protein 90 is associated with tumor aggressiveness and poor prognosis in patients with advanced gastric cancer.Identification of the NEDD4L gene as a prognostic marker by integrated microarray analysis of copy number and gene expression profiling in non-small cell lung cancer.17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway.Hsp90 molecular chaperone inhibitors: are we there yet?Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells.Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer.Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy.The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth.Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells.Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells.Genomic medicine in non-small cell lung cancer: paving the path to personalized care.Common pathogenic mechanisms and pathways in the development of COPD and lung cancer.Heat-shock protein 90 inhibitors as antitumor agents: a survey of the literature from 2005 to 2010.Enhanced antitumor activity of erlotinib in combination with the Hsp90 inhibitor CH5164840 against non-small-cell lung cancer.Identification of differentially expressed genes between lung adenocarcinoma and lung squamous cell carcinoma by gene expression profiling.DNA copy number alterations in endobronchial squamous metaplastic lesions predict lung cancer.Battling cancer on many fronts. Meeting on New Battlefields in Human Cancer--Attacking in Many Fronts.HSP90 expression and its association with wighteone metabolite response in HER2-positive breast cancer cells.Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer.The relationship between EGFR gain and VHL loss in lung adenocarcinoma and poor patient survival.A 16-gene expression signature to distinguish stage I from stage II lung squamous carcinoma.Inhibition of heat shock protein 90 exerts an antitumour effect in angiosarcoma: involvement of the vascular endothelial growth factor signalling pathway.Integrated genomic profiling identifies two distinct molecular subtypes with divergent outcome in neuroblastoma with loss of chromosome 11q HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma

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Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target

http://www.wikidata.org/entity/Q28271520

description

2008 nî lūn-bûn

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2008 թուականի Մարտին հրատարակուած գիտական յօդուած

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Integration of gene dosage and ...... n of HSP90 as potential target

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Egbert F Smit

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Gerrit A Meijer

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Giuseppe Giaccone

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Jacek Niklinski

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José A Rodriguez

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Karijn Floor

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Len Neckers

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Mariëlle I Gallegos Ruiz

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Nico van Zandwijk

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Paul Roepman

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P2860

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification

High-resolution genomic profiles of human lung cancer

Human and mouse oligonucleotide-based array CGH.

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

A gene expression signature predicts survival of patients with stage I non-small cell lung cancer

Gene-expression profiles predict survival of patients with lung adenocarcinoma

Cancer statistics, 2006

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

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