Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15
about
The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawalTHAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell deathPhosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADDAllosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket.The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell deathThe mitochondrial serine protease HtrA2/Omi: an overviewPED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1Characterization of a MAPK scaffolding protein logic gate in gonadotropes.Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state.HtrA3 Is Downregulated in Cancer Cell Lines and Significantly Reduced in Primary Serous and Granulosa Cell Ovarian Tumors.Early phosphoproteomic changes in the mouse spleen during deoxynivalenol-induced ribotoxic stressCytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL.The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia.Role of Bcl-2 family proteins and caspases in the regulation of apoptosis.Functional and molecular characterization for the damp-obstructed rat model in Chinese medicine.Targetting PED/PEA-15 for diabetes treatment.Melatonin ameliorates ischemic-like injury-evoked nitrosative stress: Involvement of HtrA2/PED pathways in endothelial cells.NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.HtrA2 enhances the apoptotic functions of p73 on bax.RETRACTED: Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity.Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development.Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death.HtrA2, taming the oncogenic activities of WT1.Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice.Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.Serine proteases and calpains fulfill important supporting roles in the apoptotic tragedy of the cellular opera.Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.The protease inhibitor Ucf-101 induces cellular responses independently of its known target, HtrA2/Omi
P2860
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P2860
Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Omi/HtrA2 promotes cell death ...... i-apoptotic protein ped/pea-15
@ast
Omi/HtrA2 promotes cell death ...... i-apoptotic protein ped/pea-15
@en
Omi/HtrA2 promotes cell death ...... i-apoptotic protein ped/pea-15
@nl
type
label
Omi/HtrA2 promotes cell death ...... i-apoptotic protein ped/pea-15
@ast
Omi/HtrA2 promotes cell death ...... i-apoptotic protein ped/pea-15
@en
Omi/HtrA2 promotes cell death ...... i-apoptotic protein ped/pea-15
@nl
prefLabel
Omi/HtrA2 promotes cell death ...... i-apoptotic protein ped/pea-15
@ast
Omi/HtrA2 promotes cell death ...... i-apoptotic protein ped/pea-15
@en
Omi/HtrA2 promotes cell death ...... i-apoptotic protein ped/pea-15
@nl
P2093
P2860
P3181
P356
P1476
Omi/HtrA2 promotes cell death ...... i-apoptotic protein ped/pea-15
@en
P2093
Alessandra Trencia
Alessia Paola Maria Barbagallo
Anna Perfetti
Antonis S Zervos
Claudia Miele
Francesca Fiory
Francesco Beguinot
Francesco Oriente
Lucia Cilenti
Maria Alessandra Maitan
P2860
P304
46566-46572
P3181
P356
10.1074/JBC.M406317200
P407
P577
2004-08-24T00:00:00Z