Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction - Wikidata - thesis-toulmin - TriplyDB

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction

http://www.wikidata.org/entity/Q28287126

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The role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancer The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2 MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling Hematopoietic stem cell: self-renewal versus differentiation Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.Single-cell STAT5 signal transduction profiling in normal and leukemic stem and progenitor cell populations reveals highly distinct cytokine responses Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells Megakaryopoiesis Lnk constrains myeloproliferative diseases in mice.The molecular regulation of Janus kinase (JAK) activation Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation.The adaptor protein SH2B3 (Lnk) negatively regulates neurite outgrowth of PC12 cells and cortical neurons.Dasatinib impairs long-term expansion of leukemic progenitors in a subset of acute myeloid leukemia cases.Association Study of rs3184504 C>T Polymorphism in Patients With Coronary Artery Disease.LNK (SH2B3): paradoxical effects in ovarian cancer.Reduced repression of cytokine signaling ameliorates age-induced decline in hematopoietic stem cell function.Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding Nov/CCN3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ3 Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1 LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration.14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B Cytokine signaling, lipid raft clustering, and HSC hibernation.SH2B3 (LNK) mutations from myeloproliferative neoplasms patients have mild loss of function against wild type JAK2 and JAK2 V617F.Bloodlines of haematopoietic stem cell research in Japan.JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms Cytokines regulating hematopoietic stem cell function.Genetic loss of SH2B3 in acute lymphoblastic leukemia.Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling.Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments.Drug-induced premature senescence model in human dental follicle stem cells.The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Role of the adaptor protein LNK in normal and malignant hematopoiesis.STAT5-mediated self-renewal of normal hematopoietic and leukemic stem cells.Bone marrow Schwann cells induce hematopoietic stem cell hibernation.

P2860

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P2860

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction

http://www.wikidata.org/entity/Q28287126

description

2007 nî lūn-bûn

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2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2007 թվականի փետրվարին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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Lnk negatively regulates self- ...... n-mediated signal transduction

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Proceedings of the National Academy of Sciences of the United States of America

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Lnk negatively regulates self- ...... n-mediated signal transduction

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Akiko Yamasaki

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Hideo Ema

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Hiromitsu Nakauchi

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Jun Ooehara

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Kiyoshi Takatsu

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Koji Eto

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Satoshi Takaki

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Satoshi Yamazaki

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Yuko Tadokoro

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P2860

Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk

Characterization of Lnk. An adaptor protein expressed in lymphocytes

Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores

Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways

Introduction to stem cell biology in vitro. Threshold to the future.

Quantitative assessment of the stem cell self-renewal capacity.

Drug synergism: its detection and applications.

Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK.

Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice.

Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis.

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2349-2354

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17284614

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1892983

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