The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology
about
Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell linesEngineering Translation in Mammalian Cell Factories to Increase Protein Yield: The Unexpected Use of Long Non-Coding SINEUP RNAsAnnotation of additional evolutionary conserved microRNAs in CHO cells from updated genomic data.The role of replicates for error mitigation in next-generation sequencing.An analysis of a 'community-driven' reconstruction of the human metabolic networkAn automated RNA-Seq analysis pipeline to identify and visualize differentially expressed genes and pathways in CHO cells.A novel regulatory element (E77) isolated from CHO-K1 genomic DNA enhances stable gene expression in Chinese hamster ovary cellsIntracellular CHO Cell Metabolite Profiling Reveals Steady-State Dependent Metabolic Fingerprints in Perfusion Culture.Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time.Multi-omic profiling -of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein productionProteins improving recombinant antibody production in mammalian cells.CHOgenome.org 2.0: Genome resources and website updates.CRISPR/Cas9-mediated genome engineering of CHO cell factories: Application and perspectives.Towards next generation CHO cell biology: Bioinformatics methods for RNA-Seq-based expression profiling.The use of 'Omics technology to rationally improve industrial mammalian cell line performance.Optimizing eukaryotic cell hosts for protein production through systems biotechnology and genome-scale modeling.Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome.Quantitative intracellular flux modeling and applications in biotherapeutic development and production using CHO cell cultures.New Mammalian Expression Systems.A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.Disruption of the gene C12orf35 leads to increased productivities in recombinant CHO cell lines.Deletion of a telomeric region on chromosome 8 correlates with higher productivity and stability of CHO cell lines.Heterologous protein production using euchromatin-containing expression vectors in mammalian cellsGene editing for cell engineering: trends and applications.Modulating carbohydrate-protein interactions through glycoengineering of monoclonal antibodies to impact cancer physiology.A framework for the systematic design of fed-batch strategies in mammalian cell culture.Cell line profiling to improve monoclonal antibody production.Global insights into the Chinese hamster and CHO cell transcriptomes.A Markov chain model for N-linked protein glycosylation--towards a low-parameter tool for model-driven glycoengineering.Proteomic differences in recombinant CHO cells producing two similar antibody fragments.Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool.Two-Dimensional Gel Electrophoresis and 2D-DIGE.The emerging role of systems biology for engineering protein production in CHO cells.Combined metabolomics and proteomics reveals hypoxia as a cause of lower productivity on scale-up to a 5000-liter CHO bioprocess.Enhanced IgG1 production by overexpression of nuclear factor kappa B inhibitor zeta (NFKBIZ) in Chinese hamster ovary cells.Kinetic Modeling of Mammalian Cell Culture Bioprocessing: The Quest to Advance Biomanufacturing.SV40 intron, a potent strong intron element that effectively increases transgene expression in transfected Chinese hamster ovary cells.Phosphopeptide Enrichment and LC-MS/MS Analysis to Study the Phosphoproteome of Recombinant Chinese Hamster Ovary Cells.Compartment-specific metabolomics for CHO reveals that ATP pools in mitochondria are much lower than in cytosol.A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture.
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P2860
The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology
description
2013 nî lūn-bûn
@nan
2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology
@ast
The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology
@en
The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology
@nl
type
label
The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology
@ast
The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology
@en
The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology
@nl
prefLabel
The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology
@ast
The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology
@en
The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology
@nl
P3181
P1476
The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology
@en
P2093
Deniz Baycin-Hizal
Michael J Betenbaugh
P304
P3181
P356
10.1016/J.COPBIO.2013.02.007
P407
P577
2013-12-01T00:00:00Z