GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
about
Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexesHuman exonuclease I is required for 5' and 3' mismatch repairDNA polymerase delta is required for human mismatch repair in vitroEvidence for involvement of HMGB1 protein in human DNA mismatch repairhMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sitesAssociation of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations.hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication fociMicrosatellite instability in colorectal cancerN-terminus of hMLH1 confers interaction of hMutLalpha and hMutLbeta with hMutSalphaMismatch repair deficiency associated with overexpression of the MSH3 geneRecognition and binding of mismatch repair proteins at an oncogenic hot spotLack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining eventsPCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cells8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha.DNA triplet repeat expansion and mismatch repairThe PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding foldsFunctional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLalpha.The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairs.Conserved properties between functionally distinct MutS homologs in yeastGenetic and biochemical analysis of Msh2p-Msh6p: role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition.Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repair'Saccharomyces cerevisiae MSH2/6 complex interacts with Holliday junctions and facilitates their cleavage by phage resolution enzymes.The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations.Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination.Identification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNANuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agentsDNA mismatch repair and mutation avoidance pathwaysMechanisms and functions of DNA mismatch repairCharacterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesIncreased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair proteinMutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshiftsAltered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant miceElevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6(-/-) small intestinal epitheliumPartial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein AATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repairIsolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalphaNucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism
P2860
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P2860
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
@ast
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
@en
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
@nl
type
label
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
@ast
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
@en
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
@nl
prefLabel
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
@ast
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
@en
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
@nl
P2093
P50
P356
P1433
P1476
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
@en
P2093
P304
P356
10.1126/SCIENCE.7604265
P407
P577
1995-06-01T00:00:00Z