about
Discovery and resupply of pharmacologically active plant-derived natural products: A reviewMEDock: a web server for efficient prediction of ligand binding sites based on a novel optimization algorithmGLIDA: GPCR-ligand database for chemical genomic drug discoveryModels for Predicting Drug Absorption From Oral Lipid-Based FormulationsProtein Folding and Mechanisms of ProteostasisFine-tuning multiprotein complexes using small moleculesPathways and progress in improving drug delivery through the intestinal mucosa and blood-brain barriersStructure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewRecent progress in the metabolic engineering of alkaloids in plant systemsSwissParam: A fast force field generation tool for small organic moleculesActivation of Inhibitors by Sortase Triggers Irreversible Modification of the Active SiteComprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-LactamaseComplementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain InhibitorsClassification of drugs based on properties of sodium channel inhibition: a comparative automated patch-clamp studyA systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological dataParallel screening of wild-type and drug-resistant targets for anti-resistance neuraminidase inhibitorsUse of natural products as chemical library for drug discovery and network pharmacologyDiscovery of potent broad spectrum antivirals derived from marine actinobacteriaIn silico repositioning-chemogenomics strategy identifies new drugs with potential activity against multiple life stages of Schistosoma mansoniA Drug-Centric View of Drug Development: How Drugs Spread from Disease to DiseaseTargeting purine and pyrimidine metabolism in human apicomplexan parasites227 Views of RNA: Is RNA Unique in Its Chemical Isomer Space?Natural products in modern life science.Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discoverySynthesis and Evaluation of a 2,11-Cembranoid-Inspired LibraryCatalytic C–H functionalization by metal carbenoid and nitrenoid insertionGlobal mapping of pharmacological spaceAdvanced Multidimensional Separations in Mass Spectrometry: Navigating the Big Data Deluge.Data-driven approaches used for compound library design, hit triage and bioactivity modeling in high-throughput screening.Solution-phase synthesis of a tricyclic pyrrole-2-carboxamide discovery library applying a stetter-Paal-Knorr reaction sequenceIdentification of novel antimicrobials using a live-animal infection modelProbing cell-division phenotype space and Polo-like kinase function using small molecules.Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher diseaseIdentification of auxins by a chemical genomics approach.Rapid multistep synthesis of 1,2,4-oxadiazoles in a single continuous microreactor sequenceSynthesis of unprecedented scaffold diversity.Design and synthesis of a library of tetracyclic hydroazulenoisoindoles.Physiochemical property space distribution among human metabolites, drugs and toxins.Principles, implementation, and application of biology-oriented synthesis (BIOS).Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Navigating chemical space for biology and medicine
@ast
Navigating chemical space for biology and medicine
@en
Navigating chemical space for biology and medicine
@nl
type
label
Navigating chemical space for biology and medicine
@ast
Navigating chemical space for biology and medicine
@en
Navigating chemical space for biology and medicine
@nl
prefLabel
Navigating chemical space for biology and medicine
@ast
Navigating chemical space for biology and medicine
@en
Navigating chemical space for biology and medicine
@nl
P2860
P3181
P356
P1433
P1476
Navigating chemical space for biology and medicine
@en
P2093
Andrew Hopkins
P2860
P2888
P304
P3181
P356
10.1038/NATURE03193
P407
P577
2004-12-16T00:00:00Z
P5875
P6179
1025290270