The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling
about
A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cellsClosing in on the biological functions of Fps/Fes and FerSpatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scatteringStructural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activationTargeted disruption of the murine fps/fes proto-oncogene reveals that Fps/Fes kinase activity is dispensable for hematopoiesis.Mice devoid of fer protein-tyrosine kinase activity are viable and fertile but display reduced cortactin phosphorylation.Enhanced endotoxin sensitivity in fps/fes-null mice with minimal defects in hematopoietic homeostasis.Activated Fes protein tyrosine kinase induces terminal macrophage differentiation of myeloid progenitors (U937 cells) and activation of the transcription factor PU.1.Downregulation of Fes inhibits VEGF-A-induced chemotaxis and capillary-like morphogenesis by cultured endothelial cells.The Fer tyrosine kinase is important for platelet-derived growth factor-BB-induced signal transducer and activator of transcription 3 (STAT3) protein phosphorylation, colony formation in soft agar, and tumor growth in vivo.Cell type-specific effects of Yersinia pseudotuberculosis virulence effectors.The integrin beta1 subunit transmembrane domain regulates phosphatidylinositol 3-kinase-dependent tyrosine phosphorylation of Crk-associated substrate.Fes tyrosine kinase promotes survival and terminal granulocyte differentiation of factor-dependent myeloid progenitors (32D) and activates lineage-specific transcription factors.Interaction between the Yersinia protein tyrosine phosphatase YopH and eukaryotic Cas/Fyb is an important virulence mechanism.The nonreceptor protein-tyrosine kinase c-Fes is involved in fibroblast growth factor-2-induced chemotaxis of murine brain capillary endothelial cells.
P2860
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P2860
The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The Fes protein-tyrosine kinas ...... hesion and cell-cell signaling
@ast
The Fes protein-tyrosine kinas ...... hesion and cell-cell signaling
@en
The Fes protein-tyrosine kinas ...... hesion and cell-cell signaling
@nl
type
label
The Fes protein-tyrosine kinas ...... hesion and cell-cell signaling
@ast
The Fes protein-tyrosine kinas ...... hesion and cell-cell signaling
@en
The Fes protein-tyrosine kinas ...... hesion and cell-cell signaling
@nl
prefLabel
The Fes protein-tyrosine kinas ...... hesion and cell-cell signaling
@ast
The Fes protein-tyrosine kinas ...... hesion and cell-cell signaling
@en
The Fes protein-tyrosine kinas ...... hesion and cell-cell signaling
@nl
P2093
P2860
P356
P1476
The Fes protein-tyrosine kinas ...... hesion and cell-cell signaling
@en
P2093
P2860
P304
P356
10.1074/JBC.272.4.2104
P407
P50
P577
1997-01-01T00:00:00Z