The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development
about
Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthasesThe Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residueStructural Ordering of Disordered Ligand-Binding Loops of Biotin Protein Ligase into Active Conformations as a Consequence of DehydrationStructural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target from Mycobacterium TuberculosisStructure of the Sensor Domain of Mycobacterium tuberculosis PknH Receptor Kinase Reveals a Conserved Binding CleftUltralong C100 mycolic acids support the assignment of Segniliparus as a new bacterial genusPhosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesisPleiotropic effect of AccD5 and AccE5 depletion in acyl-coenzyme A carboxylase activity and in lipid biosynthesis in mycobacteriaThree-dimensional in vitro models of granuloma to study bacteria-host interactions, drug-susceptibility, and resuscitation of dormant mycobacteriaIdentification of KasA as the cellular target of an anti-tubercular scaffoldComparative genome analysis provides insights into the evolution and adaptation of Pseudomonas syringae pv. aesculi on Aesculus hippocastanum.The Mycobacterium tuberculosis cytochrome P450 system.Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define the specificity of the mycolic acid elongation complexes.Involvement of two latex-clearing proteins during rubber degradation and insights into the subsequent degradation pathway revealed by the genome sequence of Gordonia polyisoprenivorans strain VH2Diversion of phagosome trafficking by pathogenic Rhodococcus equi depends on mycolic acid chain length.Phosphorylation of enoyl-acyl carrier protein reductase InhA impacts mycobacterial growth and survival.Carbon flux rerouting during Mycobacterium tuberculosis growth arrest.Identifying feasible metabolic routes in Mycobacterium smegmatis and possible alterations under diverse nutrient conditions.Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host-pathogen interactionApicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii.Molecular basis for the inhibition of β-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors.A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boostersCharacterization of Mycolic Acids in Total Fatty Acid Methyl Ester Fractions from Mycobacterium Species by High Resolution MALDI-TOFMS.Evolution of a thienopyrimidine antitubercular relying on medicinal chemistry and metabolomics insights.Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antituberculous Vaccines.Functional characterization of the Mycobacterium abscessus genome coupled with condition specific transcriptomics reveals conserved molecular strategies for host adaptation and persistenceNocardia brasiliensis cell wall lipids modulate macrophage and dendritic responses that favor development of experimental actinomycetoma in BALB/c mice.Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stressShort, Synthetic Cationic Peptides Have Antibacterial Activity against Mycobacterium smegmatis by Forming Pores in Membrane and Synergizing with Antibiotics.Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesisMolecular mechanisms of host-pathogen interactions and their potential for the discovery of new drug targetsThe Mycobacterium tuberculosis GroEL1 chaperone is a substrate of Ser/Thr protein kinases.Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexansProtein targets for structure-based anti-Mycobacterium tuberculosis drug discovery.Arabinogalactan and lipoarabinomannan biosynthesis: structure, biogenesis and their potential as drug targets.MmpL3 a potential new target for development of novel anti-tuberculosis drugs.Drug resistance to Mycobacterium tuberculosis: from the traditional Chinese view to modern systems biology.
P2860
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P2860
The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The Mycobacterium tuberculosis ...... and in future drug development
@ast
The Mycobacterium tuberculosis ...... and in future drug development
@en
The Mycobacterium tuberculosis ...... and in future drug development
@nl
type
label
The Mycobacterium tuberculosis ...... and in future drug development
@ast
The Mycobacterium tuberculosis ...... and in future drug development
@en
The Mycobacterium tuberculosis ...... and in future drug development
@nl
prefLabel
The Mycobacterium tuberculosis ...... and in future drug development
@ast
The Mycobacterium tuberculosis ...... and in future drug development
@en
The Mycobacterium tuberculosis ...... and in future drug development
@nl
P50
P3181
P1476
The Mycobacterium tuberculosis ...... and in future drug development
@en
P2093
Apoorva Bhatt
P304
P3181
P356
10.1111/J.1365-2958.2007.05761.X
P407
P577
2007-06-01T00:00:00Z