Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
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Sustained translational repression by eIF2α-P mediates prion neurodegenerationIsolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acidsIs tau ready for admission to the prion club?Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage responseSelf-propagation of pathogenic protein aggregates in neurodegenerative diseasesNeuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment.Evidence that bank vole PrP is a universal acceptor for prionsEx vivo mammalian prions are formed of paired double helical prion protein fibrils.Genesis of mammalian prions: from non-infectious amyloid fibrils to a transmissible prion diseaseN-Terminal Helix-Cap in α-Helix 2 Modulates β-State Misfolding in Rabbit and Hamster Prion ProteinsCrystal Structure of a Human Prion Protein Fragment Reveals a Motif for Oligomer FormationOral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected micePorcine prion protein amyloidGeneric amyloidogenicity of mammalian prion proteins from species susceptible and resistant to prionsPhysical, chemical and kinetic factors affecting prion infectivityIs the prevalent human prion protein 129M/V mutation a living fossil from a Paleolithic panzootic superprion pandemic?Early behavioral changes and quantitative analysis of neuropathological features in murine prion disease: stereological analysis in the albino Swiss mice model.Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein.Chronic wasting disease in bank voles: characterisation of the shortest incubation time model for prion diseases.Cytosolic PrP can participate in prion-mediated toxicityPrion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked.A simple, versatile and sensitive cell-based assay for prions from various speciesTh2-polarised PrP-specific transgenic T-cells confer partial protection against murine scrapieDirect evidence of generation and accumulation of β-sheet-rich prion protein in scrapie-infected neuroblastoma cells with human IgG1 antibody specific for β-form prion protein.Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection.N-terminal domain of prion protein directs its oligomeric association.The importance of prions.Calcium binding promotes prion protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure.The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates.Peptidome analysis of cerebrospinal fluid by LC-MALDI MSTransmission characteristics of variably protease-sensitive prionopathy.Inherited prion disease A117V is not simply a proteinopathy but produces prions transmissible to transgenic mice expressing homologous prion protein.Mechanism of amylin fibrillization enhancement by heparin.Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila.The sheddase ADAM10 is a potent modulator of prion disease.Replication and spread of CJD, kuru and scrapie agents in vivo and in cell cultureDefined α-synuclein prion-like molecular assemblies spreading in cell culture.Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestationInsights into prion biology: integrating a protein misfolding pathway with its cellular environment.Mammalian prions: tracking the infectious entities
P2860
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P2860
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
@ast
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
@en
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
@nl
type
label
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
@ast
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
@en
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
@nl
prefLabel
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
@ast
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
@en
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
@nl
P2093
P3181
P356
P1433
P1476
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
@en
P2093
Anthony R Clarke
Bernadette Sharps
Huda Al-Doujaily
John Collinge
Malin K Sandberg
P2888
P3181
P356
10.1038/NATURE09768
P407
P577
2011-02-24T00:00:00Z
P5875
P6179
1020162253